Curriculum Vitae

Dra. Cecilia Contreras Cubas

Dra. Cecilia Contreras Cubas

Investigador en Ciencias Médicas C
5350-1900 ext.1205
ccontreras@inmegen.gob.mx

Cursó la licenciatura en Biología en la Facultad de Ciencias de la UNAM; obtuvo el grado de Doctora en Ciencias Biomédicas por parte de la UNAM, y realizó un posdoctorado en el Instituto de Biotecnología de la UNAM. Actualmente es Investigadora en Ciencias Médicas “C”, adscrita al laboratorio de Inmunogenómica y Enfermedades Metabólicas del INMEGEN y miembro del Sistema Nacional de Investigadores (SNI) Nivel I.

En el 2013 inició en las líneas de investigación Genómica de las enfermedades autoinmunes, Genómica de las enfermedades metabólicas y Genómica del microbioma, englobando proyectos dirigidos a enfermedades como el lupus eritematoso sistémico y diabetes tipo 2, entre otros temas. Estas líneas han tenido contribuciones importantes, tales como la identificación de variantes propias de la población mexicana asociadas a enfermedades.
Ha publicado 15 artículos de investigación en revistas internacionales. Muchos de los resultados de las líneas mencionadas se han publicado en revistas del más alto impacto, tales como Cell y Diabetes, y cuenta con cerca de 163 citas. Ha dirigido 5 tesis, que incluyen 1 de especialidad y 4 de licenciatura. Forma parte del Consorcio binacional México-EU, SIGMA (“Slim Initiative in Genomic Medicine for the Americas, T2D chapter”).

Artículos

  • Anaya-Morua W, Villafan-Bernal JR, Ramirez-Moreno E, Garcia-Ortiz H, Martinez-Portilla RJ, Contreras-Cubas C, Martinez-Hernandez A, Centeno-Cruz F, Pedroza-Montoya FE, Orozco L, Barajas-Olmos F. Total Antioxidant Capacity in Obese and Non-Obese Subjects and Its Association with Anthropo-Metabolic Markers: Systematic Review and Meta-Analysis. Antioxidants (Basel). 2023 Jul 28; 12(8):None.

  • Reyes-Gonzalez J, Barajas-Olmos F, Garcia-Ortiz H, Magraner-Pardo L, Pons T, Moreno S, Aguirre-Cruz L, Reyes-Abrahantes A, Martinez-Hernandez A, Contreras-Cubas C, Barrios-Payan J, Ruiz-Garcia HJ, Hernandez-Pando R, Quinones-Hinojosa A, Orozco L, Abrahantes-Perez MDC. Brain Radiotoxicity-Related 15CAcBRT Gene Expression Signature Predicts Survival Prognosis of Glioblastoma Patients. Neuro Oncol. 2023 Jul 8; 1:.

  • Baca P, Barajas-Olmos F, Mirzaeicheshmeh E, Zerrweck C, Guilbert L, Sanchez EC, Flores-Huacuja M, Villafan R, Martinez-Hernandez A, Garcia-Ortiz H, Contreras-Cubas C, Centeno-Cruz F, Orozco L. DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity. Nutr Diabetes. 2022 Dec 19; 12(1):50.

  • Garcia-Ortiz H, Barajas-Olmos F, Contreras-Cubas C, Reynolds AW, Flores-Huacuja M, Snow M, Ramos-Madrigal J, Baca P, Lopez-Escobar TA, Bolnick DA, Flores-Martinez SE, Ortiz-Lopez R, Kostic AD, Villafan-Bernal JR, Galaviz-Hernandez C, Centeno-Cruz F, Garcia-Zapien AG, Monge-Cazares T, Lazalde-Ramos BP, Loeza-Becerra F, Abrahantes-Perez MD, Rangel-Villalobos H, Sosa-Macias M, Rojas-Martinez A, Martinez-Hernandez A, Orozco L. Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico. Genes (Basel). 2022 DEC; 13(12):None.

  • Askapuli A, Vilar M, Garcia-Ortiz H, Zhabagin M, Sabitov Z, Akilzhanova A, Ramanculov E, Schamiloglu U, Martinez-Hernandez A, Contreras-Cubas C, Barajas-Olmos F, Schurr TG, Zhumadilov Z, Flores-Huacuja M, Orozco L, Hawks J, Saitou N. Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia. PLoS One. 2022; 17(11):e0277771.

  • Contreras-Cubas C, Barajas-Olmos F, Frayre-Martinez MI, Siordia-Reyes G, Guizar-Sanchez CC, Garcia-Ortiz H, Orozco L, Baca V. Dysferlinopathy misdiagnosed with juvenile polymyositis in the pre-symptomatic stage of hyperCKemia: a case report and literature review. BMC Med Genomics. 2022 Jun 20; 15(1):139.

  • Jurado-Camacho PA, Cid-Soto MA, Barajas-Olmos F, Garcia-Ortiz H, Baca-Peynado P, Martinez-Hernandez A, Centeno-Cruz F, Contreras-Cubas C, Gonzalez-Villalpando ME, Saldana-Alvarez Y, Salas-Martinez G, Mendoza-Caamal EC, Gonzalez-Villalpando C, Cordova EJ, Orozco L. Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated Loci. Front Genet. 2022; 13:807381.

  • Hindy G, Dornbos P, Chaffin MD, Liu DJ, Wang M, Selvaraj MS, Zhang D, Park J, Aguilar-Salinas CA, Antonacci-Fulton L, Ardissino D, Arnett DK, Aslibekyan S, Atzmon G, Ballantyne CM, Barajas-Olmos F, Barzilai N, Becker LC, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Bown MJ, Brody JA, Broome JG, Burtt NP, Cade BE, Centeno-Cruz F, Chan E, Chang YC, Chen YI, Cheng CY, Choi WJ, Chowdhury R, Contreras-Cubas C, Cordova EJ, Correa A, Cupples LA, Curran JE, Danesh J, de Vries PS, DeFronzo RA, Doddapaneni H, Duggirala R, Dutcher SK, Ellinor PT, Emery LS, Florez JC, Fornage M, Freedman BI, Fuster V, Garay-Sevilla ME, Garcia-Ortiz H, Germer S, Gibbs RA, Gieger C, Glaser B, Gonzalez C, Gonzalez-Villalpando ME, Graff M, Graham SE, Grarup N, Groop LC, Guo X, Gupta N, Han S, Hanis CL, Hansen T, He J, Heard-Costa NL, Hung YJ, Hwang MY, Irvin MR, Islas-Andrade S, Jarvik GP, Kang HM, Kardia SLR, Kelly T, Kenny EE, Khan AT, Kim BJ, Kim RW, Kim YJ, Koistinen HA, Kooperberg C, Kuusisto J, Kwak SH, Laakso M, Lange LA, Lee J, Lee S, Lehman DM, Lemaitre RN, Linneberg A, Liu J, Loos RJF, Lubitz SA, Lyssenko V, Ma RCW, Martin LW, Martinez-Hernandez A, Mathias RA, McGarvey ST, McPherson R, Meigs JB, Meitinger T, Melander O, Metcalf GA, Mi X, Mohlke KL, Montasser ME, Moon JY, Moreno-Macias H, Morrison AC, Muzny DM, Nelson SC, Nilsson PM, O'Connell JR, Orho-Melander M, Orozco L, Palmer CNA, Palmer ND, Park CJ, Park KS, Pedersen O, Peralta JM, Peyser PA, Post WS, Preuss M, Psaty BM, Qi Q, Rao DC, Redline S, Reiner AP, Revilla-Monsalve C, Rich SS, Samani N, Schunkert H, Schurmann C, Seo D, Seo JS, Sim X, Sladek R, Small KS, So WY, Stilp AM, Tai ES, Tam CHT, Taylor KD, Teo YY, Thameem F, Tomlinson B, Tsai MY, Tuomi T, Tuomilehto J, Tusie-Luna T, Udler MS, van Dam RM, Vasan RS, Viaud Martinez KA, Wang FF, Wang X, Watkins H, Weeks DE, Wilson JG, Witte DR, Wong TY, Yanek LR, Kathiresan S, Rader DJ, Rotter JI, Boehnke M, McCarthy MI, Willer CJ, Natarajan P, Flannick JA, Khera AV, Peloso GM. Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes. Am J Hum Genet. 2022 Jan 6; 109(1):81-96.

  • Mirzaeicheshmeh E, Zerrweck C, Centeno-Cruz F, Baca-Peynado P, Martinez-Hernandez A, Garcia-Ortiz H, Contreras-Cubas C, Salas-Martinez MG, Saldana-Alvarez Y, Mendoza-Caamal EC, Barajas-Olmos F, Orozco L. Alterations of DNA methylation during adipogenesis differentiation of mesenchymal stem cells isolated from adipose tissue of patients with obesity is associated with type 2 diabetes. Adipocyte. 2021 Dec; 10(1):493-504.

  • Garcia-Ortiz H, Barajas-Olmos F, Contreras-Cubas C, Cid-Soto MA, Cordova EJ, Centeno-Cruz F, Mendoza-Caamal E, Ciceron-Arellano I, Flores-Huacuja M, Baca P, Bolnick DA, Snow M, Flores-Martinez SE, Ortiz-Lopez R, Reynolds AW, Blanchet A, Morales-Marin M, Velazquez-Cruz R, Kostic AD, Galaviz-Hernandez C, Garcia-Zapien AG, Jimenez-Lopez JC, Leon-Reyes G, Salas-Bautista EG, Lazalde-Ramos BP, Jimenez-Ruiz JL, Salas-Martinez G, Ramos-Madrigal J, Mirzaeicheshmeh E, Saldana-Alvarez Y, Del Carmen Abrahantes-Perez M, Loeza-Becerra F, Mojica-Espinosa R, Sanchez-Quinto F, Rangel-Villalobos H, Sosa-Macias M, Sanchez-Corona J, Rojas-Martinez A, Martinez-Hernandez A, Orozco L. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas. Nat Commun. 2021 Oct 12; 12(1):5942.

  • Morales-Rivera MI, Alemon-Medina R, Martinez-Hernandez A, Gomez-Garduno J, Mirzaeicheshmeh E, Altamirano-Bustamante NF, Ilizaliturri-Flores I, Mendoza-Caamal EC, Perez-Guille MG, Garcia-Alvarez R, Contreras-Cubas C, Centeno-Cruz F, Revilla-Monsalve C, Garcia-Ortiz H, Barajas-Olmos F, Orozco L. The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate. Biomed Pharmacother. 2021 Oct; 142:112009.

  • Mendoza-Caamal EC, Barajas-Olmos F, Mirzaeicheshmeh E, Ilizaliturri-Flores I, Aguilar-Salinas CA, Gomez-Velasco DV, Ciceron-Arellano I, Resendiz-Rodriguez A, Martinez-Hernandez A, Contreras-Cubas C, Islas-Andrade S, Zerrweck C, Garcia-Ortiz H, Orozco L. Two novel variants in DYRK1B causative of AOMS3: expanding the clinical spectrum. Orphanet J Rare Dis. 2021 Jun 30; 16(1):291.

  • Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, Barajas-Olmos F, Barzilai N, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Centeno-Cruz F, Chambers JC, Chami N, Chan E, Chan J, Cheng CY, Cho YS, Contreras-Cubas C, Cordova E, Correa A, DeFronzo RA, Duggirala R, Dupuis J, Garay-Sevilla ME, Garcia-Ortiz H, Gieger C, Glaser B, Gonzalez-Villalpando C, Gonzalez ME, Grarup N, Groop L, Gross M, Haiman C, Han S, Hanis CL, Hansen T, Heard-Costa NL, Henderson BE, Hernandez JMM, Hwang MY, Islas-Andrade S, Jorgensen ME, Kang HM, Kim BJ, Kim YJ, Koistinen HA, Kooner JS, Kuusisto J, Kwak SH, Laakso M, Lange L, Lee JY, Lee J, Lehman DM, Linneberg A, Liu J, Loos RJF, Lyssenko V, Ma RCW, Martinez-Hernandez A, Meigs JB, Meitinger T, Mohlke KL, Morris AD, Morrison AC, Ng MCY, Nilsson PM, O'Donnell CJ, Orozco L, Palmer CNA, Park KS, Post WS, Pedersen O, Preuss M, Psaty BM, Reiner AP, Revilla-Monsalve C, Rich SS, Rotter JI, Saleheen D, Schurmann C, Sim X, Sladek R, Small KS, So WY, Spector TD, Strauch K, Strom TM, Tai ES, Tam CHT, Teo YY, Thameem F, Tomlinson B, Tracy RP, Tuomi T, Tuomilehto J, Tusie-Luna T, van Dam RM, Vasan RS, Wilson JG, Witte DR, Wong TY, Burtt NP, Zaitlen N, McCarthy MI, Boehnke M, Pollin TI, Flannick J, Mercader JM, O'Donnell-Luria A, Baxter S, Florez JC, MacArthur DG, Udler MS. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021 Jun 9; 12(1):3505.

  • Wibowo MC, Yang Z, Borry M, Hubner A, Huang KD, Tierney BT, Zimmerman S, Barajas-Olmos F, Contreras-Cubas C, Garcia-Ortiz H, Martinez-Hernandez A, Luber JM, Kirstahler P, Blohm T, Smiley FE, Arnold R, Ballal SA, Pamp SJ, Russ J, Maixner F, Rota-Stabelli O, Segata N, Reinhard K, Orozco L, Warinner C, Snow M, LeBlanc S, Kostic AD. Reconstruction of ancient microbial genomes from the human gut. Nature. 2021 Jun; 594(7862):234-239.

  • Mendoza-Caamal EC, Barajas-Olmos F, Garcia-Ortiz H, Ciceron-Arellano I, Martinez-Hernandez A, Cordova EJ, Esparza-Aguilar M, Contreras-Cubas C, Centeno-Cruz F, Cid-Soto M, Morales-Marin ME, Resendiz-Rodriguez A, Jimenez-Ruiz JL, Salas-Martinez MG, Saldana-Alvarez Y, Mirzaeicheshmeh E, Rojas-Martinez MR, Orozco L. Metabolic syndrome in indigenous communities in Mexico: a descriptive and cross-sectional study. BMC Public Health. 2020 Mar 17; 20(1):339.

  • Salas-Martinez MG, Saldana-Alvarez Y, Cordova EJ, Mendiola-Soto DK, Cid-Soto MA, Luckie-Duque A, Vicenteno-Ayala H, Barajas-Olmos F, Contreras-Cubas C, Garcia-Ortiz H, Jimenez-Ruiz JL, Centeno-Cruz F, Martinez-Hernandez A, Mendoza-Caamal EC, Mirzaeicheshmeh E, Orozco L. Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population. PLoS One. 2019; 14(12):e0225030.

  • Contreras-Cubas C, Garcia-Ortiz H, Velazquez-Cruz R, Barajas-Olmos F, Baca P, Martinez-Hernandez A, Barbosa-Cobos RE, Ramirez-Bello J, Lopez-Hernandez MA, Svyryd Y, Mutchinick OM, Baca V, Orozco L. Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans. Sci Rep. 2019 Aug 21; 9(1):12165.

  • Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Cordova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, Garcia-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jorgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Martinez-Hernandez A, Matsuo K, Mayer-Davis E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O'Dushlaine C, Payne AJ, Pihoker C, Post WS, Preuss M, Psaty BM, Vasan RS, Rayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberon X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong TY, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng CY, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehman DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan JCN, Dupuis J, Frossard P, Heckbert SR, Hwang MY, Kim YJ, Kirchner HL, Lee JY, Lee J, Loos RJF, Ma RCW, Morris AD, O'Donnell CJ, Palmer CNA, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusie-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich SS, Rotter JI, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019 Jun; 570(7759):71-76.

  • Martinez-Hernandez A, Larrosa J, Barajas-Olmos F, Garcia-Ortiz H, Mendoza-Caamal EC, Contreras-Cubas C, Mirzaeicheshmeh E, Lezana JL, Orozco L. Next-generation sequencing for identifying a novel/de novo pathogenic variant in a Mexican patient with cystic fibrosis: a case report. BMC Med Genomics. 2019 May 22; 12(1):68.

  • Cid-Soto MA, Martinez-Hernandez A, Garcia-Ortiz H, Cordova EJ, Barajas-Olmos F, Centeno-Cruz F, Contreras-Cubas C, Mendoza-Caamal EC, Ciceron-Arellano I, Morales-Rivera MI, Jimenez-Ruiz JL, Salas-Martinez G, Saldana-Alvarez Y, Revilla-Monsalve C, Islas-Andrade S, Orozco L. Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos. Gene. 2018 Dec 30; 679:160-171.

  • Martagón AJ., Bello-Chavolla OY., Arellano-Campos O., Almeda-Valdés P., Walford GA., Cruz-Bautista I., Gómez-Velasco DV., Mehta R., Muñoz-Hernández L., Sevilla-González M., Viveros-Ruiz TL., Ordoñez-Sánchez ML., Rodríguez-Guillen R., Florez JC., Tusié-Luna MT., Aguilar-Salinas CA, Mercader JM., Huerta-Chagoya A., Moreno-Macías H., García-Ortiz H., Manning A., Caulkins L., Flannick J., Patterson N., Martínez-Hernández A., Centeno-Cruz F., Barajas-Olmos FM., Zerrweck C., Contreras-Cubas C., Mendoza-Caamal E., Revilla-Monsalve C., Islas Andrade S., Córdova E, . Soberón X., González-Villalpando ME., Wilkens L., Le Marchand L., Monroe K., Kolonel L., Rodríguez-Torres M., Segura-Kato Y., Muñoz-Hernández LL, Martagón AJ, Sevilla Gonzalez MDR, Gómez D, Almeda-Valdés P, Garay ME, Malacara Hernandez JM, Burtt NP, Cortes ML, Altshuler DM, Haiman CA, González-Villalpando C, Orozco L., Tusié-Luna T. Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas. Am J Med Genet. 2018; 41(8):.

  • Mercader JM, Liao RG, Bell AD, Dymek Z, Estrada K, Tukiainen T, Huerta-Chagoya A, Moreno-Macias H, Jablonski KA, Hanson RL, Walford GA, Moran I, Chen L, Agarwala V, Ordonez-Sanchez ML, Rodriguez-Guillen R, Rodriguez-Torres M, Segura-Kato Y, Garcia-Ortiz H, Centeno-Cruz F, Barajas-Olmos F, Caulkins L, Puppala S, Fontanillas P, Williams AL, Bonas-Guarch S, Hartl C, Ripke S, Tooley K, Lane J, Zerrweck C, Martinez-Hernandez A, Cordova EJ, Contreras-Cubas C, Gonzalez-Villalpando ME, Cruz-Bautista I, Munoz-Hernandez L, Gomez-Velasco D, Alvirde U, Henderson BE, Wilkens LR, Le Marchand L, Arellano-Campos O, Riba L, Harden M, Gabriel S, Abboud HE, Cortes ML, Revilla-Monsalve C, Islas-Andrade S, Soberon X, Curran JE, Jenkinson CP, DeFronzo RA, Lehman DM, Hanis CL, Bell GI, Boehnke M, Blangero J, Duggirala R, Saxena R, MacArthur D, Ferrer J, McCarroll SA, Torrents D, Knowler WC, Baier LJ, Burtt N, Gonzalez-Villalpando C, Haiman CA, Aguilar-Salinas CA, Tusie-Luna T, Flannick J, Jacobs SBR, Orozco L, Altshuler D, Florez JC. A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes. Diabetes. 2017 Nov; 66(11):2903-2914.

Ha colaborado en proyectos y/o publicaciones con:

Dr. Humberto García Ortiz
Número de colaboraciones: 4
Dr. Emilio Joaquín Cordova Alarcón
Número de colaboraciones: 2
Dra. Mirelle Vanessa Gonzalez Covarrubias
Número de colaboraciones: 1
Mtra. Anallely Muñoz Rivas
Número de colaboraciones: 1

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