Cursó la licenciatura en Biología en la Facultad de Ciencias de la Universidad Nacional Autónoma de México, obtuvo el grado de Maestría y Doctorado en Ciencias en la Facultad de Medicina de la Universidad Nacional Autónoma de México. Realizó diferentes estancias de investigación en el Centro de Biología Molecular “Severo Ochoa”. Universidad Autónoma de Madrid, Madrid, España y en el Lawrence Livermore National Laboratory en Livermore, CA, USA.

Actualmente esta adscrita al laboratorio Inmunogenómica y enfermedades metabólicas del INMEGEN, es Investigadora en Ciencias Médicas “D” y miembro del Sistema Nacional de Investigadores (SNI) Nivel II. 

Desde el 2008 participa en diferentes  líneas de investigación  como son:  Genómica de enfermedades metabólica, enfermedades raras y genómica de poblaciones. Ha publicado  67 artículos de investigación en revistas internacionales y nacionales, muchos de ellos publicados en  revistas de alto impacto, como Nature, Cell, JAMA, Heliyon, Diabetes Care. Forma parte de los consorcios internacionales SIGMA Type 2 Diabetes Consortium y ExAc (Exome Agregation Consortium). Ha dirigido 21 tesis: 8 de posgrado y 11 de licenciatura y,  desde el 2017 es profesor adjunto del Curso de Posgrado de Alta Especialidad en Medicina Genómica, Facultad de Medicina, UNAM.

Artículos

• Anaya-Morua W, Villafan-Bernal JR, Ramirez-Moreno E, Garcia-Ortiz H, Martinez-Portilla RJ, Contreras-Cubas C, Martinez-Hernandez A, Centeno-Cruz F, Pedroza-Montoya FE, Orozco L, Barajas-Olmos F. Total Antioxidant Capacity in Obese and Non-Obese Subjects and Its Association with Anthropo-Metabolic Markers: Systematic Review and Meta-Analysis. Antioxidants (Basel). 2023 Jul 28; 12(8):None.

• Reyes-Gonzalez J, Barajas-Olmos F, Garcia-Ortiz H, Magraner-Pardo L, Pons T, Moreno S, Aguirre-Cruz L, Reyes-Abrahantes A, Martinez-Hernandez A, Contreras-Cubas C, Barrios-Payan J, Ruiz-Garcia HJ, Hernandez-Pando R, Quinones-Hinojosa A, Orozco L, Abrahantes-Perez MDC. Brain Radiotoxicity-Related 15CAcBRT Gene Expression Signature Predicts Survival Prognosis of Glioblastoma Patients. Neuro Oncol. 2023 Jul 8; 1:.

• Sanchez EC, Barajas-Olmos F, Baca P, Zerrweck C, Guilbert L, Martinez-Hernandez A, Centeno F, Orozco L. DNA Methylation Remodeling after Bariatric Surgery Correlates with Clinical Parameters. Adv Biol (Weinh). 2023 May 5; :e2300001.

• Sanchez S, Juarez U, Dominguez J, Molina B, Barrientos R, Martinez-Hernandez A, Carnevale A, Grether-Gonzalez P, Mayen DG, Villarroel C, Lieberman E, Yokoyama E, Del Castillo V, Torres L, Frias S. Frequent copy number variants in a cohort of Mexican-Mestizo individuals. Mol Cytogenet. 2023 Jan 12; 16(1):2.

• Juarez-Luis J, Canseco-Ocana M, Cid-Soto MA, Castro-Martinez XH, Martinez-Hernandez A, Orozco L, Hernandez-Zavala A, Cordova EJ. Single nucleotide variants in microRNA biosynthesis genes in Mexican individuals. Front Genet. 2023; 14:1022912.

• Baca P, Barajas-Olmos F, Mirzaeicheshmeh E, Zerrweck C, Guilbert L, Sanchez EC, Flores-Huacuja M, Villafan R, Martinez-Hernandez A, Garcia-Ortiz H, Contreras-Cubas C, Centeno-Cruz F, Orozco L. DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity. Nutr Diabetes. 2022 Dec 19; 12(1):50.

• Garcia-Ortiz H, Barajas-Olmos F, Contreras-Cubas C, Reynolds AW, Flores-Huacuja M, Snow M, Ramos-Madrigal J, Baca P, Lopez-Escobar TA, Bolnick DA, Flores-Martinez SE, Ortiz-Lopez R, Kostic AD, Villafan-Bernal JR, Galaviz-Hernandez C, Centeno-Cruz F, Garcia-Zapien AG, Monge-Cazares T, Lazalde-Ramos BP, Loeza-Becerra F, Abrahantes-Perez MD, Rangel-Villalobos H, Sosa-Macias M, Rojas-Martinez A, Martinez-Hernandez A, Orozco L. Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico. Genes (Basel). 2022 DEC; 13(12):None.

• Askapuli A, Vilar M, Garcia-Ortiz H, Zhabagin M, Sabitov Z, Akilzhanova A, Ramanculov E, Schamiloglu U, Martinez-Hernandez A, Contreras-Cubas C, Barajas-Olmos F, Schurr TG, Zhumadilov Z, Flores-Huacuja M, Orozco L, Hawks J, Saitou N. Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia. PLoS One. 2022; 17(11):e0277771.

• Martinez-Hernandez A, Martinez-Anaya D, Duran-McKinster C, Del Castillo-Ruiz V, Navarrete-Meneses P, Cordova EJ, Villegas-Torres BE, Ruiz-Herrera A, Juarez-Velazquez R, Yokoyama-Rebollar E, Cervantes-Barragan D, Pedraza-Melendez A, Orozco L, Perez-Vera P, Salas-Labadia C. Pigmentary mosaicism as a recurrent clinical manifestation in three new patients with mosaic trisomy 12 diagnosed postnatally: cases report and literature review. BMC Med Genomics. 2022 Oct 31; 15(1):224.

• Jurado-Camacho PA, Cid-Soto MA, Barajas-Olmos F, Garcia-Ortiz H, Baca-Peynado P, Martinez-Hernandez A, Centeno-Cruz F, Contreras-Cubas C, Gonzalez-Villalpando ME, Saldana-Alvarez Y, Salas-Martinez G, Mendoza-Caamal EC, Gonzalez-Villalpando C, Cordova EJ, Orozco L. Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated Loci. Front Genet. 2022; 13:807381.

• Hindy G, Dornbos P, Chaffin MD, Liu DJ, Wang M, Selvaraj MS, Zhang D, Park J, Aguilar-Salinas CA, Antonacci-Fulton L, Ardissino D, Arnett DK, Aslibekyan S, Atzmon G, Ballantyne CM, Barajas-Olmos F, Barzilai N, Becker LC, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Bown MJ, Brody JA, Broome JG, Burtt NP, Cade BE, Centeno-Cruz F, Chan E, Chang YC, Chen YI, Cheng CY, Choi WJ, Chowdhury R, Contreras-Cubas C, Cordova EJ, Correa A, Cupples LA, Curran JE, Danesh J, de Vries PS, DeFronzo RA, Doddapaneni H, Duggirala R, Dutcher SK, Ellinor PT, Emery LS, Florez JC, Fornage M, Freedman BI, Fuster V, Garay-Sevilla ME, Garcia-Ortiz H, Germer S, Gibbs RA, Gieger C, Glaser B, Gonzalez C, Gonzalez-Villalpando ME, Graff M, Graham SE, Grarup N, Groop LC, Guo X, Gupta N, Han S, Hanis CL, Hansen T, He J, Heard-Costa NL, Hung YJ, Hwang MY, Irvin MR, Islas-Andrade S, Jarvik GP, Kang HM, Kardia SLR, Kelly T, Kenny EE, Khan AT, Kim BJ, Kim RW, Kim YJ, Koistinen HA, Kooperberg C, Kuusisto J, Kwak SH, Laakso M, Lange LA, Lee J, Lee S, Lehman DM, Lemaitre RN, Linneberg A, Liu J, Loos RJF, Lubitz SA, Lyssenko V, Ma RCW, Martin LW, Martinez-Hernandez A, Mathias RA, McGarvey ST, McPherson R, Meigs JB, Meitinger T, Melander O, Metcalf GA, Mi X, Mohlke KL, Montasser ME, Moon JY, Moreno-Macias H, Morrison AC, Muzny DM, Nelson SC, Nilsson PM, O'Connell JR, Orho-Melander M, Orozco L, Palmer CNA, Palmer ND, Park CJ, Park KS, Pedersen O, Peralta JM, Peyser PA, Post WS, Preuss M, Psaty BM, Qi Q, Rao DC, Redline S, Reiner AP, Revilla-Monsalve C, Rich SS, Samani N, Schunkert H, Schurmann C, Seo D, Seo JS, Sim X, Sladek R, Small KS, So WY, Stilp AM, Tai ES, Tam CHT, Taylor KD, Teo YY, Thameem F, Tomlinson B, Tsai MY, Tuomi T, Tuomilehto J, Tusie-Luna T, Udler MS, van Dam RM, Vasan RS, Viaud Martinez KA, Wang FF, Wang X, Watkins H, Weeks DE, Wilson JG, Witte DR, Wong TY, Yanek LR, Kathiresan S, Rader DJ, Rotter JI, Boehnke M, McCarthy MI, Willer CJ, Natarajan P, Flannick JA, Khera AV, Peloso GM. Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes. Am J Hum Genet. 2022 Jan 6; 109(1):81-96.

• Gallegos-Cabriales EC, Rodriguez-Ayala E, Laviada-Molina HA, Nava-Gonzalez EJ, Salinas-Osornio RA, Orozco L, Leal-Berumen I, Castillo-Pineda JC, Gonzalez-Lopez L, Escudero-Lourdes C, Cornejo-Barrera J, Escalante-Araiza F, Huerta-Avila EE, Buenfil-Rello FA, Peschard VG, Silva E, Veloz-Garza RA, Martinez-Hernandez A, Barajas-Olmos FM, Molina-Segui F, Gonzalez-Ramirez L, Arjona-Villicana RD, Hernandez-Escalante VM, Gaytan-Saucedo JF, Vaquera Z, Acebo-Martinez M, Murillo-Ramirez A, Diaz-Tena SP, Figueroa-Nunez B, Valencia-Rendon ME, Garzon-Zamora R, Viveros-Paredes JM, Valdovinos-Chavez SB, Comuzzie AG, Haack K, Thorsell AA, Han X, Cole SA, Bastarrachea RA. Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults. Biology (Basel). 2021 Dec 16; 10(12):None.

• Mirzaeicheshmeh E, Zerrweck C, Centeno-Cruz F, Baca-Peynado P, Martinez-Hernandez A, Garcia-Ortiz H, Contreras-Cubas C, Salas-Martinez MG, Saldana-Alvarez Y, Mendoza-Caamal EC, Barajas-Olmos F, Orozco L. Alterations of DNA methylation during adipogenesis differentiation of mesenchymal stem cells isolated from adipose tissue of patients with obesity is associated with type 2 diabetes. Adipocyte. 2021 Dec; 10(1):493-504.

• Garcia-Ortiz H, Barajas-Olmos F, Contreras-Cubas C, Cid-Soto MA, Cordova EJ, Centeno-Cruz F, Mendoza-Caamal E, Ciceron-Arellano I, Flores-Huacuja M, Baca P, Bolnick DA, Snow M, Flores-Martinez SE, Ortiz-Lopez R, Reynolds AW, Blanchet A, Morales-Marin M, Velazquez-Cruz R, Kostic AD, Galaviz-Hernandez C, Garcia-Zapien AG, Jimenez-Lopez JC, Leon-Reyes G, Salas-Bautista EG, Lazalde-Ramos BP, Jimenez-Ruiz JL, Salas-Martinez G, Ramos-Madrigal J, Mirzaeicheshmeh E, Saldana-Alvarez Y, Del Carmen Abrahantes-Perez M, Loeza-Becerra F, Mojica-Espinosa R, Sanchez-Quinto F, Rangel-Villalobos H, Sosa-Macias M, Sanchez-Corona J, Rojas-Martinez A, Martinez-Hernandez A, Orozco L. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas. Nat Commun. 2021 Oct 12; 12(1):5942.

• Morales-Rivera MI, Alemon-Medina R, Martinez-Hernandez A, Gomez-Garduno J, Mirzaeicheshmeh E, Altamirano-Bustamante NF, Ilizaliturri-Flores I, Mendoza-Caamal EC, Perez-Guille MG, Garcia-Alvarez R, Contreras-Cubas C, Centeno-Cruz F, Revilla-Monsalve C, Garcia-Ortiz H, Barajas-Olmos F, Orozco L. The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate. Biomed Pharmacother. 2021 Oct; 142:112009.

• Mendoza-Caamal EC, Barajas-Olmos F, Mirzaeicheshmeh E, Ilizaliturri-Flores I, Aguilar-Salinas CA, Gomez-Velasco DV, Ciceron-Arellano I, Resendiz-Rodriguez A, Martinez-Hernandez A, Contreras-Cubas C, Islas-Andrade S, Zerrweck C, Garcia-Ortiz H, Orozco L. Two novel variants in DYRK1B causative of AOMS3: expanding the clinical spectrum. Orphanet J Rare Dis. 2021 Jun 30; 16(1):291.

• Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, Barajas-Olmos F, Barzilai N, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Centeno-Cruz F, Chambers JC, Chami N, Chan E, Chan J, Cheng CY, Cho YS, Contreras-Cubas C, Cordova E, Correa A, DeFronzo RA, Duggirala R, Dupuis J, Garay-Sevilla ME, Garcia-Ortiz H, Gieger C, Glaser B, Gonzalez-Villalpando C, Gonzalez ME, Grarup N, Groop L, Gross M, Haiman C, Han S, Hanis CL, Hansen T, Heard-Costa NL, Henderson BE, Hernandez JMM, Hwang MY, Islas-Andrade S, Jorgensen ME, Kang HM, Kim BJ, Kim YJ, Koistinen HA, Kooner JS, Kuusisto J, Kwak SH, Laakso M, Lange L, Lee JY, Lee J, Lehman DM, Linneberg A, Liu J, Loos RJF, Lyssenko V, Ma RCW, Martinez-Hernandez A, Meigs JB, Meitinger T, Mohlke KL, Morris AD, Morrison AC, Ng MCY, Nilsson PM, O'Donnell CJ, Orozco L, Palmer CNA, Park KS, Post WS, Pedersen O, Preuss M, Psaty BM, Reiner AP, Revilla-Monsalve C, Rich SS, Rotter JI, Saleheen D, Schurmann C, Sim X, Sladek R, Small KS, So WY, Spector TD, Strauch K, Strom TM, Tai ES, Tam CHT, Teo YY, Thameem F, Tomlinson B, Tracy RP, Tuomi T, Tuomilehto J, Tusie-Luna T, van Dam RM, Vasan RS, Wilson JG, Witte DR, Wong TY, Burtt NP, Zaitlen N, McCarthy MI, Boehnke M, Pollin TI, Flannick J, Mercader JM, O'Donnell-Luria A, Baxter S, Florez JC, MacArthur DG, Udler MS. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021 Jun 9; 12(1):3505.

• Wibowo MC, Yang Z, Borry M, Hubner A, Huang KD, Tierney BT, Zimmerman S, Barajas-Olmos F, Contreras-Cubas C, Garcia-Ortiz H, Martinez-Hernandez A, Luber JM, Kirstahler P, Blohm T, Smiley FE, Arnold R, Ballal SA, Pamp SJ, Russ J, Maixner F, Rota-Stabelli O, Segata N, Reinhard K, Orozco L, Warinner C, Snow M, LeBlanc S, Kostic AD. Reconstruction of ancient microbial genomes from the human gut. Nature. 2021 Jun; 594(7862):234-239.

• Rodriguez-Ayala E, Gallegos-Cabrales EC, Gonzalez-Lopez L, Laviada-Molina HA, Salinas-Osornio RA, Nava-Gonzalez EJ, Leal-Berumen I, Escudero-Lourdes C, Escalante-Araiza F, Buenfil-Rello FA, Peschard VG, Laviada-Nagel A, Silva E, Veloz-Garza RA, Martinez-Hernandez A, Barajas-Olmos FM, Molina-Segui F, Gonzalez-Ramirez L, Espadas-Olivera R, Lopez-Munoz R, Arjona-Villicana RD, Hernandez-Escalante VM, Rodriguez-Arellano ME, Gaytan-Saucedo JF, Vaquera Z, Acebo-Martinez M, Cornejo-Barrera J, Huertas-Quintero JA, Castillo-Pineda JC, Murillo-Ramirez A, Diaz-Tena SP, Figueroa-Nunez B, Valencia-Rendon ME, Garzon-Zamora R, Viveros-Paredes JM, Angeles-Chimal J, Santa-Olalla Tapia J, Remes-Troche JM, Valdovinos-Chavez SB, Huerta-Avila EE, Lopez-Alvarenga JC, Comuzzie AG, Haack K, Han X, Orozco L, Weintraub S, Kent JW, Cole SA, Bastarrachea RA. Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study. Adipocyte. 2020 Dec; 9(1):153-169.

• Mendoza-Caamal EC, Barajas-Olmos F, Garcia-Ortiz H, Ciceron-Arellano I, Martinez-Hernandez A, Cordova EJ, Esparza-Aguilar M, Contreras-Cubas C, Centeno-Cruz F, Cid-Soto M, Morales-Marin ME, Resendiz-Rodriguez A, Jimenez-Ruiz JL, Salas-Martinez MG, Saldana-Alvarez Y, Mirzaeicheshmeh E, Rojas-Martinez MR, Orozco L. Metabolic syndrome in indigenous communities in Mexico: a descriptive and cross-sectional study. BMC Public Health. 2020 Mar 17; 20(1):339.

• Rivera-Paredez B, Hidalgo-Bravo A, de la Cruz-Montoya A, Martinez-Aguilar MM, Ramirez-Salazar EG, Flores M, Quezada-Sanchez AD, Ramirez-Palacios P, Cid M, Martinez-Hernandez A, Orozco L, Denova-Gutierrez E, Salmeron J, Velazquez-Cruz R. Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women. J Endocrinol Invest. 2020 Jul; 43(7):935-946.

• Escalante-Araiza F., Barajas-Olmos F., Martínez-Hernández A., Huerta-Ávila E., Peschard V-G., Rodríguez-Ayala E., Bastarrachea RA., Orozco L.. MON-708 Characterizing DNA Methylation Signatures in Adipose Tissue from Metabolic Impaired Asymptomatic Individuals. Am J Med Genet. 2020 ABRIL; 4(1):None.

• Salas-Martinez MG, Saldana-Alvarez Y, Cordova EJ, Mendiola-Soto DK, Cid-Soto MA, Luckie-Duque A, Vicenteno-Ayala H, Barajas-Olmos F, Contreras-Cubas C, Garcia-Ortiz H, Jimenez-Ruiz JL, Centeno-Cruz F, Martinez-Hernandez A, Mendoza-Caamal EC, Mirzaeicheshmeh E, Orozco L. Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population. PLoS One. 2019; 14(12):e0225030.

• Gonzalez-Covarrubias V, Morales-Franco M, Cruz-Correa OF, Martinez-Hernandez A, Garcia-Ortiz H, Barajas-Olmos F, Genis-Mendoza AD, Martinez-Magana JJ, Nicolini H, Orozco L, Soberon X. Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico. Front Pharmacol. 2019; 10:1169.

• Martinez-Magana JJ, Genis-Mendoza AD, Tovilla-Zarate CA, Gonzalez-Castro TB, Juarez-Rojop IE, Hernandez-Diaz Y, Martinez-Hernandez AG, Garcia-Ortiz H, Orozco L, Lopez-Narvaez ML, Nicolini H. Association between APOE polymorphisms and lipid profile in Mexican Amerindian population. Mol Genet Genomic Med. 2019 Nov; 7(11):e958.

• Contreras-Cubas C, Garcia-Ortiz H, Velazquez-Cruz R, Barajas-Olmos F, Baca P, Martinez-Hernandez A, Barbosa-Cobos RE, Ramirez-Bello J, Lopez-Hernandez MA, Svyryd Y, Mutchinick OM, Baca V, Orozco L. Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans. Sci Rep. 2019 Aug 21; 9(1):12165.

• De la Torre-Garcia O, Mar-Aldama R, Salgado-Sangri R, Diaz-Gomez N, Bonilla-Arcaute L, Diaz-Ponce-Medrano J, Guevara-Yanez R, Cordova EJ, Monge-Cazares T, Orozco L, Martinez-Hernandez A. A homozygous CEP57 c.915_925dupCAATGTTCAGC mutation in a patient with mosaic variegated aneuploidy syndrome with rhizomelic shortening in the upper and lower limbs and a narrow thorax. Eur J Med Genet. 2019 Jul 17; 1:.

• Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Cordova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, Garcia-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jorgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Martinez-Hernandez A, Matsuo K, Mayer-Davis E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O'Dushlaine C, Payne AJ, Pihoker C, Post WS, Preuss M, Psaty BM, Vasan RS, Rayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberon X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong TY, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng CY, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehman DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan JCN, Dupuis J, Frossard P, Heckbert SR, Hwang MY, Kim YJ, Kirchner HL, Lee JY, Lee J, Loos RJF, Ma RCW, Morris AD, O'Donnell CJ, Palmer CNA, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusie-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich SS, Rotter JI, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019 Jun; 570(7759):71-76.

• Martinez-Hernandez A, Larrosa J, Barajas-Olmos F, Garcia-Ortiz H, Mendoza-Caamal EC, Contreras-Cubas C, Mirzaeicheshmeh E, Lezana JL, Orozco L. Next-generation sequencing for identifying a novel/de novo pathogenic variant in a Mexican patient with cystic fibrosis: a case report. BMC Med Genomics. 2019 May 22; 12(1):68.

• Berumen J, Orozco L, Betancourt-Cravioto M, Gallardo H, Zulueta M, Mendizabal L, Simon L, Benuto RE, Ramirez-Campos E, Marin M, Juarez E, Garcia-Ortiz H, Martinez-Hernandez A, Venegas-Vega C, Peralta-Romero J, Cruz M, Tapia-Conyer R. Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study. Sci Rep. 2019 Feb 26; 9(1):2748.

• Bastarrachea RA, Laviada-Molina HA, Nava-Gonzalez EJ, Leal-Berumen I, Escudero-Lourdes C, Escalante-Araiza F, Peschard VG, Veloz-Garza RA, Haack K, Martinez-Hernandez A, Barajas-Olmos FM, Molina-Segui F, Buenfil-Rello FA, Gonzalez-Ramirez L, Janssen-Aguilar R, Lopez-Munoz R, Perez-Cetina F, Gaytan-Saucedo JF, Vaquera Z, Cornejo-Barrera J, Castillo-Pineda JC, Murillo-Ramirez A, Diaz-Tena SP, Figueroa-Nunez B, Gonzalez-Lopez L, Salinas-Osornio RA, Valencia-Rendon ME, Angeles-Chimal J, Santa-Olalla Tapia J, Remes-Troche JM, Valdovinos-Chavez SB, Huerta-Avila EE, Han X, Orozco L, Rodriguez-Ayala E, Weintraub S, Gallegos-Cabrales EC, Cole SA, Kent JW Jr. Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design. Genes (Basel). 2018 Nov 2; 9(11):.

• Cid-Soto MA, Martinez-Hernandez A, Garcia-Ortiz H, Cordova EJ, Barajas-Olmos F, Centeno-Cruz F, Contreras-Cubas C, Mendoza-Caamal EC, Ciceron-Arellano I, Morales-Rivera MI, Jimenez-Ruiz JL, Salas-Martinez G, Saldana-Alvarez Y, Revilla-Monsalve C, Islas-Andrade S, Orozco L. Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos. Gene. 2018 Dec 30; 679:160-171.

• Rivera-Paredez B, Macias N, Martinez-Aguilar MM, Hidalgo-Bravo A, Flores M, Quezada-Sanchez AD, Denova-Gutierrez E, Cid M, Martinez-Hernandez A, Orozco L, Quiterio M, Flores YN, Salmeron J, Velazquez-Cruz R. Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women. Nutrients. 2018 Aug 27; 10(9):.

• Martagón AJ., Bello-Chavolla OY., Arellano-Campos O., Almeda-Valdés P., Walford GA., Cruz-Bautista I., Gómez-Velasco DV., Mehta R., Muñoz-Hernández L., Sevilla-González M., Viveros-Ruiz TL., Ordoñez-Sánchez ML., Rodríguez-Guillen R., Florez JC., Tusié-Luna MT., Aguilar-Salinas CA, Mercader JM., Huerta-Chagoya A., Moreno-Macías H., García-Ortiz H., Manning A., Caulkins L., Flannick J., Patterson N., Martínez-Hernández A., Centeno-Cruz F., Barajas-Olmos FM., Zerrweck C., Contreras-Cubas C., Mendoza-Caamal E., Revilla-Monsalve C., Islas Andrade S., Córdova E, . Soberón X., González-Villalpando ME., Wilkens L., Le Marchand L., Monroe K., Kolonel L., Rodríguez-Torres M., Segura-Kato Y., Muñoz-Hernández LL, Martagón AJ, Sevilla Gonzalez MDR, Gómez D, Almeda-Valdés P, Garay ME, Malacara Hernandez JM, Burtt NP, Cortes ML, Altshuler DM, Haiman CA, González-Villalpando C, Orozco L., Tusié-Luna T. Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas. Am J Med Genet. 2018; 41(8):.

• Barajas-Olmos F, Centeno-Cruz F, Zerrweck C, Imaz-Rosshandler I, Martinez-Hernandez A, Cordova EJ, Rangel-Escareno C, Galvez F, Castillo A, Maydon H, Campos F, Maldonado-Pintado DG, Orozco L. Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes. BMC Med Genet. 2018 Feb 21; 19(1):28.

• Genis-Mendoza AD., Martínez-Magaña JJ., Bojórquez C., Téllez-Martínez JA., Jiménez-Genchi J., Roche A., Bojorge A., Chávez M., Castañeda C., Guzmán R., Zapata L., Aguilar-Méndez D., Lanzagorta N., Rebolledo I., Castro-Chavira S., Fernández T., Orozco L., Nicolini H., Martínez-Hernández AG.. Programa de detección del alelo APOE-E4 en adultos mayores mexicanos con deterioro cognitivo.. Gac Med Mex. 2018 2018; 154(5):None.

• Palma-Cano LE, Cordova EJ, Orozco L, Martinez-Hernandez A, Cid M, Leal-Berumen I, Licon-Trillo A, Lechuga-Valles R, Gonzalez-Ponce M, Gonzalez-Rodriguez E, Moreno-Brito V. GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review. Genet Mol Biol. 2017 Oct-Dec; 40(4):727-735.

• Romero-Hidalgo S, Ochoa-Leyva A, Garciarrubio A, Acuna-Alonzo V, Antunez-Arguelles E, Balcazar-Quintero M, Barquera-Lozano R, Carnevale A, Cornejo-Granados F, Fernandez-Lopez JC, Garcia-Herrera R, Garcia-Ortiz H, Granados-Silvestre A, Granados J, Guerrero-Romero F, Hernandez-Lemus E, Leon-Mimila P, Macin-Perez G, Martinez-Hernandez A, Menjivar M, Morett E, Orozco L, Ortiz-Lopez G, Perez-Villatoro F, Rivera-Morales J, Riveros-McKay F, Villalobos-Comparan M, Villamil-Ramirez H, Villarreal-Molina T, Canizales-Quinteros S, Soberon X. Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing. Nat Commun. 2017 Oct 18; 8(1):1005.

• Mercader JM, Liao RG, Bell AD, Dymek Z, Estrada K, Tukiainen T, Huerta-Chagoya A, Moreno-Macias H, Jablonski KA, Hanson RL, Walford GA, Moran I, Chen L, Agarwala V, Ordonez-Sanchez ML, Rodriguez-Guillen R, Rodriguez-Torres M, Segura-Kato Y, Garcia-Ortiz H, Centeno-Cruz F, Barajas-Olmos F, Caulkins L, Puppala S, Fontanillas P, Williams AL, Bonas-Guarch S, Hartl C, Ripke S, Tooley K, Lane J, Zerrweck C, Martinez-Hernandez A, Cordova EJ, Contreras-Cubas C, Gonzalez-Villalpando ME, Cruz-Bautista I, Munoz-Hernandez L, Gomez-Velasco D, Alvirde U, Henderson BE, Wilkens LR, Le Marchand L, Arellano-Campos O, Riba L, Harden M, Gabriel S, Abboud HE, Cortes ML, Revilla-Monsalve C, Islas-Andrade S, Soberon X, Curran JE, Jenkinson CP, DeFronzo RA, Lehman DM, Hanis CL, Bell GI, Boehnke M, Blangero J, Duggirala R, Saxena R, MacArthur D, Ferrer J, McCarroll SA, Torrents D, Knowler WC, Baier LJ, Burtt N, Gonzalez-Villalpando C, Haiman CA, Aguilar-Salinas CA, Tusie-Luna T, Flannick J, Jacobs SBR, Orozco L, Altshuler D, Florez JC. A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes. Diabetes. 2017 Nov; 66(11):2903-2914.

• Contreras-Cubas C, Sanchez-Hernandez BE, Garcia-Ortiz H, Martinez-Hernandez A, Barajas-Olmos F, Cid M, Mendoza-Caamal EC, Centeno-Cruz F, Ortiz-Cruz G, Jimenez-Lopez JC, Cordova EJ, Salas-Bautista EG, Saldana-Alvarez Y, Fernandez-Lopez JC, Mutchinick OM, Orozco L. Heterogenous Distribution of MTHFR Gene Variants among Mestizos and Diverse Amerindian Groups from Mexico. PLoS One. 2016; 11(9):e0163248.

• Gutierrez-Malacatt H, Ayala-Sanchez M, Aquino-Ortega X, Dominguez-Rodriguez J, Martinez-Tovar A, Olarte-Carrillo I, Martinez-Hernandez A, C CC, Orozco L, Cordova EJ. The rs61764370 Functional Variant in the KRAS Oncogene is Associated with Chronic Myeloid Leukemia Risk in Women. Asian Pac J Cancer Prev. 2016; 17(4):2265-70.

• Moran J, Ramirez G, Jimenez L, Cruz A, Perez-Patrigeon S, Hidalgo A, Orozco L, Martinez A, Padilla L, Avila-Moreno F, Cabello C, Granados J, Ortiz-Quintero B, Ramirez-Venegas A, Ruiz-Palacios GM, Zlotnik A, Merino E, Zuniga J. Circulating levels of miR-150 are associated with poorer outcomes of A/H1N1 infection. Exp Mol Pathol. 2015 Jul 3; 99(2):253-261.

• Martinez-Hernandez A, Cordova EJ, Rosillo-Salazar O, Garcia-Ortiz H, Contreras-Cubas C, Islas-Andrade S, Revilla-Monsalve C, Salas-Labadia C, Orozco L. Association of HMOX1 and NQO1 Polymorphisms with Metabolic Syndrome Components. PLoS One. 2015; 10(5):e0123313.

• Morales-Marin ME, Cordova EJ, Centeno F, Martinez-Hernandez A, Mendez-Garcia A, Molina B, Frias S, Orozco L. NFE2L2 Gene Variants and Arsenic Susceptibility: A Lymphoblastoid Model. J Toxicol Environ Health A. 2015; 78(10):628-34.

• Estrada K, Aukrust I, Bjorkhaug L, Burtt NP, Mercader JM, Garcia-Ortiz H, Huerta-Chagoya A, Moreno-Macias H, Walford G, Flannick J, Williams AL, Gomez-Vazquez MJ, Fernandez-Lopez JC, Martinez-Hernandez A, Centeno-Cruz F, Revilla-Monsalve C, Islas-Andrade S, Cordova EJ, Soberon X, Gonzalez-Villalpando ME, Henderson E, Wilkens LR, Le Marchand L, Arellano-Campos O, Ordonez-Sanchez ML, Rodriguez-Torres M, Rodriguez-Guillen R, Riba L, Najmi LA, Jacobs SB, Fennell T, Gabriel S, Fontanillas P, Hanis CL, Lehman DM, Jenkinson CP, Abboud HE, Bell GI, Cortes ML, Boehnke M, Gonzalez-Villalpando C, Orozco L, Haiman CA, Tusie-Luna T, Aguilar-Salinas CA, Altshuler D, Njolstad PR, Florez JC, MacArthur DG. Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population. JAMA. 2014 Jun 11; 311(22):2305-2314.

• Cordova EJ, Martinez-Hernandez A, Uribe-Figueroa L, Centeno F, Morales-Marin M, Koneru H, Coleman MA, Orozco L. The NRF2-KEAP1 Pathway Is an Early Responsive Gene Network in Arsenic Exposed Lymphoblastoid Cells. PLoS One. 2014; 9(2):e88069.

• Williams AL, Jacobs SB, Moreno-Macias H, Huerta-Chagoya A, Churchhouse C, Marquez-Luna C, Garcia-Ortiz H, Jose Gomez-Vazquez M, Burtt NP, Aguilar-Salinas CA, Gonzalez-Villalpando C, Florez JC, Orozco L, Haiman CA, Tusie-Luna T, Altshuler D, Ripke S, Manning AK, Neale B, Reich D, Stram DO, Fernandez-Lopez JC, Romero-Hidalgo S, Patterson N, Aguilar-Delfin I, Martinez-Hernandez A, Centeno-Cruz F, Revilla-Monsalve C, Islas-Andrade S, Cordova E, Rodriguez-Arellano E, Soberon X, Gonzalez-Villalpando ME, Henderson BE, Monroe K, Wilkens L, Kolonel LN, Le Marchand L, Riba L, Ordonez-Sanchez ML, Rodriguez-Guillen R, Cruz-Bautista I, Rodriguez-Torres M, Munoz-Hernandez LL, Saenz T, Gomez D, Alvirde U, Onofrio RC, Brodeur WM, Gage D, Murphy J, Franklin J, Mahan S, Ardlie K, Crenshaw AT, Winckler W, Prufer K, Shunkov MV, Sawyer S, Stenzel U, Kelso J, Lek M, Sankararaman S, Macarthur DG, Derevianko AP, Paabo S, Gopal S, Grammatikos JA, Smith IC, Bullock KH, Deik AA, Souza AL, Pierce KA, Clish CB, Fennell T, Farjoun Y, Genomics Platform B, Gabriel S, Gross MD, Pereira MA, Seielstad M, Koh WP, Tai ES, Flannick J, Fontanillas P, Morris A, Teslovich TM, Atzmon G, Blangero J, Bowden DW, Chambers J, Shin Cho Y, Duggirala R, Glaser B, Hanis C, Kooner J, Laakso M, Lee JY, Ying Teo Y, Wilson JG, Puppala S, Farook VS, Thameem F, Abboud HE, Defronzo RA, Jenkinson CP, Lehman DM, Curran JE, Cortes ML. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature. 2013 Dec 25; 506(7486):97-101.

• Martinez A, Coleman M, Romero-Talamas CA, Frias S. An assessment of immediate DNA damage to occupationally exposed workers to low dose ionizing radiation by using the comet assay.. Rev Invest Clin. 2010 Jan-Feb; 62(1):23-30.

• Martinez A, Ramos S, Gonzalez-del Angel A, Alcantara MA, Molina B, Carnevale A. Duplication 2p and monosomy 8p in mosaicism: clinical, molecular cytogenetic and molecular markers of a unique case. Rev Invest Clin. 2007 Nov-Dec; 59(6):444-8.

• Urraca N, Arenas-Sordo Mde L, Ortiz-Dominguez A, Martinez A, Molina B, Galvez A, Nicolini H. An 8q21 deletion in a patient with comorbid psychosis and mental retardation. CNS Spectr. 2005 Nov; 10(11):864-6.

• Martinez Angelica, Blanco Beatriz, Frias Sara, ora Maria Antonieta, Carnevale Alessandra. Assessment Of Immediate Dna Damage To Workers Occupationall Exposed To Radiation Using The Alkaline Unicellular Electrophoresis Technique. Mutat Res. 2004; :0-0.

• Perez-Vera P, Mujica-Sanchez M, Carnevale A, Rivera-Luna R, Paredes R, Martinez A, Frias S. Cytogenetics in acute lymphoblastic leukemia in Mexican children: an institutional experience. Arch Med Res. 2001 May-Jun; 32(3):202-7.

Servicio Social

• Ernaxani Arcos Guevara
• Ximena Luna González

Estancia Voluntaria

• Adrián Baustista Astorga

Práctica Profesional

• María Dolores Rebollar García

En curso

• Bases genómicas del metabolismo postrandial
• DIVERSIDAD GENÓMICA Y VARIANTES RARAS QUE CONTRIBUYEN AL DESARROLLO DE LAS ENFERMEDADES CRÓNICO-DEGENERATIVAS EN LOS GRUPOS INDÍGENAS DEL TERRITORIO MEXICANO
• ESTRUCTURA DEL GENOMA MITOCONDRIAL EN POBLACIONES AMERINDIAS DE MÉXICO: IDENTIFICACION DE HAPLOGRUPOS ASOCIADOS A ENFERMEDADES COMUNES
• Evaluación del impacto de la dieta tradicional e industrializada en la diversidad de la microbiota intestinal y su efecto en la predisposición a enfermedades metabólicas en población mexicana
• GENÓMICA, METABOLÓMICA, Y MICROBIOMA DE LOS TRASTORNOS DE LA CONDUCTA ALIMENTARIA Y OBESIDAD
• IDENTIFICACIÓN DE ALTERACIONES PERSISTENTES EN LA METILACIÓN DE DNA DURANTE LA DIFERENCIACIÓN DEL ADIPOCITO EN PACIENTES OBESOS DIABÉTICOS Y NO DIABÉTICOS
• IDENTIFICACIÓN DE BIOMARCADORES DE SUSCEPTIBILIDAD PARA DIABETES MELLITUS TIPO 2 Y OBESIDAD, MEDIANTE LA CARACTERIZACIÓN DE PERFILES DE EXPRESIÓN, EPIGENÓMICOS Y METABOLÓMICOS.
• Identificación del espectro total de mutaciones del gen CFTR y asociación de genes modificadores con la gravedad de fibrosis quística en pacientes mexicanos
• Identificación de Variantes Patogénicas Responsables de Errores Innatos del Metabolismo en Población Mexicana: Frecuencia de Portadores y Estimación de Prevalencia
• Perfil de expresión diferencial de microRNAs en plasma de adultos con síndrome metabólico. MODALIDAD: PROYECTO DE GRUPO
• Predictor de riesgo poligénico como una herramienta genómica para la identificación de individuos mexicanos susceptibles a lupus eritematoso sistémico
• predictor de riesgo poligénico para identificar a individuos mexicanos susceptibles a diabetes tipo 2
• Remodelación de la metilación de DNA en tejido adiposo de pacientes obesos con Diabetes Mellitus tipo 2 después de cirugía bariátrica

Terminados

• Bases genómicas del Síndrome Metabólico en la Población Mexicana
• Caracterización de variabilidad genética en población indígena mexicana (100G-MX)
• DIABETES MÉXICO Iniciativa del Instituto Carlos Slim para la Salud
• ESTUDIO INTEGRAL DEL GENOMA, PROTEOMA Y METABOLOMA EN ABORTOS Y NACIDOS VIVOS CON ANEUPLOIDÍAS. BÚSQUEDA DE BIOMARCADORES NO INVASIVOS.
• Factores genéticos amerindios y variantes raras que contribuyen al desarrollo de la diabetes mellitus tipo 2 en familias indígenas rurales de la Cd. de México.
• Identificación de variantes funcionales en genes candidato asociados con el riesgo al desarrollo de síndrome metabólico en grupos indígenas y población mestiza mexicana
• PROYECTO DE CONTINUIDAD: ANÁLISIS DE VARIANTES GÉNICAS ASOCIADAS A DIABETES EN LA POBLACIÓN INDÍGENA MEXICANA.