Cursó la licenciatura en Investigación Biomédica Básica de la Facultad de Medicina de la Universidad Nacional Autónoma de México (UNAM); obtuvo el grado de Doctorado en Ciencias en la UNAM, así como el posdoctorado en la Facultad de Medicina de Harvard University. Actualmente es Investigador en Ciencias Médicas “C”, adscrito al laboratorio de Vesículas Extracelulares y Comunicación Celular del INMEGEN y miembro del Sistema Nacional de Investigadores (SNI) Nivel I.

Desde 2015 colabora en las líneas de investigación de Genómica de enfermedades neurodegenerativas y Proteómica, englobando proyectos dirigidos a la búsqueda de biomarcadores, al entendimiento del papel funcional de los exosomas en enfermedades degenerativas y a la caracterización de las bases genéticas de la enfermedad de Parkinson.
Ha publicado 14 artículos de investigación en revistas internacionales y nacionales y 4 capítulos de libro. Muchos de los resultados de las líneas mencionados se han publicado en revistas del más alto impacto, tales como Journal of Phisiology, ATVB, Plos One y PNAS y cuenta con cerca de 156 citas. Ha dirigido 1 tesis de licenciatura. Desde 2016 es profesor del Posgrado de Ciencias Biológicas de la UNAM.

Artículos

• Cruz-Burgos M, Cortes-Ramirez SA, Losada-Garcia A, Morales-Pacheco M, Martinez-Martinez E, Morales-Montor JG, Servin-Haddad A, Izquierdo-Luna JS, Rodriguez-Martinez G, Ramos-Godinez MDP, Gonzalez-Covarrubias V, Canavera-Constantino A, Gonzalez-Ramirez I, Su B, Leong HS, Rodriguez-Dorantes M. Unraveling the Role of EV-Derived miR-150-5p in Prostate Cancer Metastasis and Its Association with High-Grade Gleason Scores: Implications for Diagnosis. Cancers (Basel). 2023 Aug 17; 15(16):None.

• Martinez-Greene JA, Gomez-Chavarin M, Ramos-Godinez MDP, Martinez-Martinez E. Isolation of Hepatic and Adipose-Tissue-Derived Extracellular Vesicles Using Density Gradient Separation and Size Exclusion Chromatography. Int J Mol Sci. 2023 Aug 11; 24(16):None.

• Lopez-Hernandez Y, Monarrez-Espino J, Lopez DAG, Zheng J, Borrego JC, Torres-Calzada C, Elizalde-Diaz JP, Mandal R, Berjanskii M, Martinez-Martinez E, Lopez JA, Wishart DS. The plasma metabolome of long COVID patients two years after infection. Sci Rep. 2023 Aug 1; 13(1):12420.

• Garcia-Hernandez LA, Martinez-Martinez E, Pazos-Solis D, Aguado-Preciado J, Dutt A, Chavez-Ramirez AU, Korgel B, Sharma A, Oza G. Optical Detection of Cancer Cells Using Lab-on-a-Chip. Biosensors (Basel). 2023 Mar 30; 13(4):None.

• Gonzalez-Pedroza MG, Benitez ART, Navarro-Marchal SA, Martinez-Martinez E, Marchal JA, Boulaiz H, Morales-Luckie RA. Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications. Sci Rep. 2023 Jan 16; 13(1):790.

• Carapia AK, Martinez-Colin EJ, Segura-Villalobos D, Victoria-Chavez RY, Lezama I, Martinez-Martinez E, Lamas M. Muller Glia to Muller Glia Extracellular Vesicle-Dependent Signaling Induces Multipotency Genes Nestin and lin28 Expression in Response to N-methyl-D-aspartate (NMDA) Exposure. ASN Neuro. 2023 Jan-Dec; 15:17590914231183272.

• Elizalde-Diaz JP, Miranda-Narvaez CL, Martinez-Lazcano JC, Martinez-Martinez E. The relationship between chronic immune response and neurodegenerative damage in long COVID-19. Front Immunol. 2022 DEC 16; 13:None.

• Perez-Macedonio CP, Flores-Alfaro E, Alarcon-Romero LD, Vences-Velazquez A, Castro-Alarcon N, Martinez-Martinez E, Ramirez M. CD 14 and CD26 from serum exosomes are associated with type 2 diabetes, exosomal Cystatin C and CD14 are associated with metabolic syndrome and atherogenic index of plasma. PeerJ. 2022 JUL 12; 10:None.

• Gonzalez-Covarrubias V, Martinez-Martinez E, Del Bosque-Plata L. The Potential of Metabolomics in Biomedical Applications. Metabolites. 2022 Feb 19; 12(2):None.

• Ballinas-Verdugo MA, Jimenez-Ortega RF, Martinez-Martinez E, Rivas N, Contreras-Lopez EA, Carbo R, Sanchez F, Bojalil R, Marquez-Velasco R, Sanchez-Munoz F, Alejandre-Aguilar R. Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease. Biol Res. 2021 Jul 21; 54(1):21.

• Del Bosque-Plata L, Martinez-Martinez E, Espinoza-Camacho MA, Gragnoli C. The Role of TCF7L2 in Type 2 Diabetes. Diabetes. 2021 Jun; 70(6):1220-1228.

• Hernandez-Diazcouder A, Gonzalez-Ramirez J, Giacoman-Martinez A, Cardoso-Saldana G, Martinez-Martinez E, Osorio-Alonso H, Marquez-Velasco R, Sanchez-Gloria JL, Juarez-Vicuna Y, Gonzaga G, Sanchez-Lozada LG, Almanza-Perez JC, Sanchez-Munoz F. High fructose exposure modifies the amount of adipocyte-secreted microRNAs into extracellular vesicles in supernatants and plasma. PeerJ. 2021; 9:e11305.

• Gonzalez-Pedroza MG, Argueta-Figueroa L, Garcia-Contreras R, Jimenez-Martinez Y, Martinez-Martinez E, Navarro-Marchal SA, Marchal JA, Morales-Luckie RA, Boulaiz H. Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool. Nanomaterials (Basel). 2021 May 12; 11(5):.

• Velazquez-Vazquez DE, Del Moral-Morales A, Cruz-Burgos JM, Martinez-Martinez E, Rodriguez-Dorantes M, Camacho-Alpharroyo I. Expression analysis of progesteroneregulated miRNAs in cells derived from human glioblastoma. Mol Med Rep. 2021 Jun; 23(6):.

• Martinez-Greene JA, Hernandez-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godinez MDP, Martinez-Martinez E. Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. J Extracell Vesicles. 2021 Apr; 10(6):e12087.

• Quiroz-Baez R, Hernandez-Ortega K, Martinez-Martinez E. Insights Into the Proteomic Profiling of Extracellular Vesicles for the Identification of Early Biomarkers of Neurodegeneration. Front Neurol. 2020; 11:580030.

• Herrera-Van Oostdam AS, Toro-Ortiz JC, Lopez JA, Noyola DE, Garcia-Lopez DA, Duran-Figueroa NV, Martinez-Martinez E, Portales-Perez DP, Salgado-Bustamante M, Lopez-Hernandez Y. Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation. Int J Mol Med. 2020 Aug; 46(2):546-560.

• Castillo X, Castro-Obregon S, Gutierrez-Becker B, Gutierrez-Ospina G, Karalis N, Khalil AA, Lopez-Noguerola JS, Rodriguez LL, Martinez-Martinez E, Perez-Cruz C, Perez-Velazquez J, Pina AL, Rubio K, Garcia HPS, Syeda T, Vanoye-Carlo A, Villringer A, Winek K, Zille M. Re-thinking the Etiological Framework of Neurodegeneration. Front Neurosci. 2019; 13:728.

• Nagy E, Lei Y, Martinez-Martinez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E. Interferon-gamma Released by Activated CD8(+) T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves. Am J Pathol. 2017 Jun; 187(6):1413-1425.

• Brianza-Padilla M, Carbo R, Arana JC, Vazquez-Palacios G, Ballinas-Verdugo MA, Cardoso-Saldana GC, Palacio AG, Juarez-Vicuna Y, Sanchez F, Martinez-Martinez E, Huang F, Sanchez-Munoz F, Bojalil R. Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. Biomed Res Int. 2016; 2016:2489479.

• Krohn JB, Hutcheson JD, Martinez-Martinez E, Aikawa E. Extracellular vesicles in cardiovascular calcification: expanding current paradigms. J Physiol. 2016 Jun 1; 594(11):2895-903.

• Krohn JB, Hutcheson JD, Martinez-Martinez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E. Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-beta Signaling. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):525-33.

• Martinez-Martinez E, Uribe-Querol E, Galvan-Hernandez CI, Gutierrez-Ospina G. Stereological Quantification of Cell-Cycle Kinetics and Mobilization of Epithelial Stem Cells during Wound Healing. Methods Mol Biol. 2016; 1453:93-107.

• Martinez-Martinez E, Zaragoza ML, Solano E, Figueroa B, Zuniga P, Laclette JP. Health research funding in Mexico: the need for a long-term agenda. PLoS One. 2012; 7(12):e51195.

• Martinez-Martinez E, Galvan-Hernandez CI, Toscano-Marquez B, Gutierrez-Ospina G. Modulatory role of sensory innervation on hair follicle stem cell progeny during wound healing of the rat skin. PLoS One. 2012; 7(5):e36421.

• Martinez-Martinez E, Toscano-Marquez B, Gutierrez-Ospina G. Long-term effects of neonatal capsaicin treatment on intraepidermal nerve fibers and keratinocyte proliferation in rat glabrous skin. Anat Rec (Hoboken). 2011 Jan; 294(1):173-84.

• Toscano-Marquez B, Martinez-Martinez E, Manjarrez E, Martinez L, Mendoza-Torreblanca J, Gutierrez-Ospina G. Late onset muscle plasticity in the whisker pad of enucleated rats. Proc Natl Acad Sci USA. 2008 Oct 14; 105(41):15973-8.

• Mendoza-Torreblanca JG, Martinez-Martinez E, Tapia-Rodriguez M, Ramirez-Hernandez R, Gutierrez-Ospina G. The rostral migratory stream is a neurogenic niche that predominantly engenders periglomerular cells: in vivo evidence in the adult rat brain. Neurosci Res. 2008 Mar; 60(3):289-99.

• Uribe-Querol E, Martinez-Martinez E, Tapia-Rodriguez M, Hernandez LR, Toscano-Marquez B, Padilla P, Gutierrez-Ospina G. Metabolic indices shift in the hypothalamic-neurohypophysial system during lactation: implications for interpreting their relationship with neuronal activity. Neuroscience. 2005; 134(4):1217-22.

• Zomosa-Signoret V, Hernandez-Alcantara G, Reyes-Vivas H, Martinez-Martinez E, Garza-Ramos G, Perez-Montfort R, Tuena De Gomez-Puyou M, Gomez-Puyou A. Control of the reactivation kinetics of homodimeric triosephosphate isomerase from unfolded monomers. Biochemistry. 2003 Mar 25; 42(11):3311-8.

• Reyes-Vivas H, Martinez-Martinez E, Mendoza-Hernandez G, Lopez-Velazquez G, Perez-Montfort R, Tuena de Gomez-Puyou M, Gomez-Puyou A. Susceptibility to proteolysis of triosephosphate isomerase from two pathogenic parasites: characterization of an enzyme with an intact and a nicked monomer. Proteins. 2002 Aug 15; 48(3):580-90.

Estancia Posdoctoral

• José Pedro Elizalde Díaz
• Luis Angel Carvajal Oliveros

Tesista de Doctorado

• Ana Karen Carapia Hernández

Servicio Social

• Alain Ortíz López

Estancia Voluntaria

• Ariadna Mendoza Ascencio

En curso

• Bases genéticas de la enfermedad de Parkinson en la población mexicana: hacia un enfoque proteogenómico para la búsqueda de biomarcadores

Terminados

• Análisis de vesículas extracelulares con perspectiva de uso en diagnóstico y terapia molecular
• Análisis proteómico y funcional de vesículas extracelulares: implicaciones fisiológicas de la comunicación intercelular en la diabetes.
• Análisis sistemático de vesículas extracelulares con perspectiva de uso en la terapia molecular basada en RNA para el tratamiento de la enfermedad de Parkinson y Diabetes Tipo 2.
• Desarrollo de tecnologías para el cargado de complejos ribonucleoproteínicos en vesículas extracelulares para su uso como vehículos de entrega a células en cultivo.
• Identificación de biomarcadores presentes en exosomas en familias con historial de diabetes y enfermedad de Parkinson