Es Bióloga, egresada de la Universidad Autónoma Metropolitana-Xochimilco. Posteriormente, realizó estudios de Maestría y Doctorado con la especialidad en Biología Celular en el Departamento de Biología Celular en el CINVESTAV-Zacatenco. Realizó una estancia de investigación doctoral durante un año en el Department of Biology, College of Staten Island (CUNY), New York, United States.

Actualmente, es Investigadora en Ciencias Médicas C en el laboratorio de Genómica del Metabolismo Óseo, en el Instituto Nacional de Medicina Genómica. Forma parte del Sistema Nacional de Investigadoras e Investigadores Nivel I. Ha publicado 28 artículos de investigación y 1 capítulo de libro.

Las líneas de investigación en las que participa son:

1. Búsqueda de biomarcadores tempranos con un enfoque proteómico para el diagnóstico de osteoporosis en mujeres postmenopáusicas.
2. Efecto de los patrones dietarios en la microbiota intestinal de individuos portadores de variantes en los genes PNPLA3, TM6SF2 y MBOAT7 y su impacto en el desarrollo de enfermedad hepática esteatósica asociada a disfunción metabólica (MASLD).
3. Efecto de los campos electromagnéticos sobre la neurodegeneración en modelos in vitro e in vivo.

Artículos

• Lopez-Perez TV, Jimenez-Ortega RF, Cruz-Rangel A, Aparicio-Bautista DI, Fernandez-Lopez JC, Becerra-Cervera A, Reyes-Grajeda JP, Salmeron J, Hidalgo-Bravo A, Rivera-Paredez B, Velazquez-Cruz R. Serum Calcium Concentration Is Associated with Bone Mineral Density and Synonymous Variants in the RYR1 Gene in a Mexican-Mestizo Population. Med Sci (Basel). 2025 Dec 24; 13(4):None.

• Aparicio-Bautista DI, Salmeron J, Jimenez-Ortega RF, Lopez-Perez TV, Becerra-Cervera A, Velazquez-Cruz R, Rivera-Paredez B. Association between advanced glycation end products and bone mineral density in Mexican population. Bone. 2025 Dec 18; 0:117763.

• Meneses-Leon J, Quezada-Sanchez AD, Rojas-Russel M, Aparicio-Bautista DI, Velazquez-Cruz R, Aguilar-Salinas CA, Salmeron J, Rivera-Paredez B. Cross-Lagged Relationship Between Adiposity and HOMA and Mediating Role of Adiposity Between Lifestyle Factors and HOMA Among in Mexican Health Workers. Nutrients. 2025 Jul 30; 17(15):None.

• Becerra-Cervera A, Jimenez-Ortega RF, Aparicio-Bautista DI, Palacios-Gonzalez B, Vela-Amieva M, Ibarra-Gonzalez I, Canizales-Quinteros S, Salmeron J, Rivera-Paredez B, Velazquez-Cruz R. Gut microbiota changes in postmenopausal women with low bone density linked to serum amino acid metabolism. Front Cell Infect Microbiol. 2025; 15:1627519.

• Alejandro MM, Herlinda BJ, Aparicio-Bautista DI, Siddhartha MR, Overduin M, Basurto-Islas G. Molecular mechanisms associated with the interaction of external electromagnetic fields in protein dynamics and aggregation: a focus on amyloid-betapeptide. Prog Biomed Eng (Bristol). 2025 Jul 17; 7(3):None.

• Jimenez-Ortega RF, Aparicio-Bautista DI, Becerra-Cervera A, Ortega-Melendez AI, Patino N, Rivera-Paredez B, Hidalgo-Bravo A, Velazquez-Cruz R. The Regulatory Role of Long Non-Coding RNAs in the Development and Progression of Osteoporosis. Int J Mol Sci. 2025 Apr 30; 26(9):None.

• Becerra-Cervera A, Jimenez-Ortega RF, Aparicio-Bautista DI, Lopez-Perez TV, Patino N, Castillejos-Lopez M, Hidalgo-Bravo A, Denova-Gutierrez E, Salmeron J, Rivera-Paredez B, Velazquez-Cruz R. Genetic variants in vitamin D metabolism-related genes are associated with vitamin D status and adiposity markers. Nutr Res. 2025 Apr; 136:105-119.

• Jimenez-Ortega RF, Lopez-Perez TV, Becerra-Cervera A, Aparicio-Bautista DI, Patino N, Salas-Martinez G, Salmeron J, Velazquez-Cruz R, Rivera-Paredez B. Impact of the dietary antioxidant index on bone mineral density gain among mexican adults: a prospective study. Arch Osteoporos. 2025 Mar 11; 20(1):38.

• Jimenez-Ortega RF, Meneses-Leon J, Hernandez S, Thebar-Moreno P, Aparicio-Bautista DI, Becerra-Cervera A, Aguilar-Salinas C, Salmeron J, Rivera-Paredez B, Velazquez-Cruz R. High dietary antioxidant index associated with reduced insulin resistance in female Mexican children and adolescents. Nutr Res. 2024 Oct 26; 132:53-66.

• Becerra-Cervera A, Argoty-Pantoja AD, Aparicio-Bautista DI, Lopez-Montoya P, Rivera-Paredez B, Hidalgo-Bravo A, Velazquez-Cruz R. Proteomic Biomarkers Associated with Low Bone Mineral Density: A Systematic Review. Int J Mol Sci. 2024 Jul 9; 25(14):None.

• Aparicio-Bautista DI, Jimenez-Ortega RF, Becerra-Cervera A, Aquino-Galvez A, de Leon-Suarez VP, Casas-Avila L, Salmeron J, Hidalgo-Bravo A, Rivera-Paredez B, Velazquez-Cruz R. Interaction between MARK3 (rs11623869), PLCB4 (rs6086746) and GEMIN2 (rs2277458) variants with bone mineral density and serum 25-hidroxivitamin D levels in Mexican Mestizo women. Front Endocrinol (Lausanne). 2024 May 08; 15:1392063.

• Aparicio-Bautista DI, Becerra-Cervera A, Rivera-Paredez B, Aguilar-Ordonez I, Rios-Castro E, Reyes-Grajeda JP, Salmeron J, Hidalgo-Bravo A, Velazquez-Cruz R. Label-free quantitative proteomics in serum reveals candidate biomarkers associated with low bone mineral density in Mexican postmenopausal women. Geroscience. 2024 Apr; 46(2):2177-2195.

• Idelfonso-Garcia OG, Alarcon-Sanchez BR, Guerrero-Escalera D, Lopez-Hernandez NA, Perez-Hernandez JL, Pacheco-Rivera R, Serrano-Luna J, Resendis-Antonio O, Mucino-Olmos EA, Aparicio-Bautista DI, Basurto-Islas G, Baltierrez-Hoyos R, Vasquez-Garzon VR, Villa-Trevino S, Muriel P, Serrano H, Perez-Carreon JI, Arellanes-Robledo J. Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver. Antioxidants (Basel). 2024 Feb 20; 13(3):None.

• Jimenez-Ortega RF, Aparicio-Bautista DI, Becerra-Cervera A, Lopez-Montoya P, Leon-Reyes G, Flores-Morales J, Castillejos-Lopez M, Hidalgo-Bravo A, Salmeron J, Rivera-Paredez B, Velazquez-Cruz R. Association Study between Antioxidant Nutrient Intake and Low Bone Mineral Density with Oxidative Stress-Single Nucleotide Variants: GPX1 (rs1050450 and rs17650792), SOD2 (rs4880) and CAT (rs769217) in Mexican Women. Antioxidants (Basel). 2023 Dec 23; 12(12):None.

• Briones-Orta MA, Avendano-Vazquez SE, Aparicio-Bautista DI, Coombes JD, Weber GF, Syn WK. Osteopontin splice variants and polymorphisms in cancer progression and prognosis. Biochim Biophys Acta Rev Cancer. 2017 Aug; 1868(1):93-108.A.

• Jimenez-Garcia MN, Arellanes-Robledo J, Aparicio-Bautista DI, Rodriguez-Segura MA, Villa-Trevino S, Godina-Nava JJ. Anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liver. BMC Cancer. 2010 Apr 27; 10:159.

• Vasquez-Garzon VR, Arellanes-Robledo J, Garcia-Roman R, Aparicio-Rautista DI, Villa-Trevino S. Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism. Free Radic Res. 2008 Dec 31; 43(2):128-37.

Estancia Voluntaria

• Yduskya Donaji Velázquez Santamaría

Servicio Social

• Ana Belen Cabello Tapia
• Eduardo Calderón Morales
• Ricardo Martínez Vera