Nombre completo: Linda Nelly Patiño Uriostegui.

Adscripción: Subdirección de Investigación Médica.

Mail de contacto: lnpatino@inmegen.gob.mx 

Teléfono de contacto: 53501900 Ext. 1190

Responsable de la Unidad de Citometría de Flujo (UCiF) del Instituto Nacional de Medicina Genómica desde  el 2010.

Tiempo de experiencia en citometría de flujo: 16 años

Investigadora en ciencias Medias B desde 2010.

Maestría en Ciencias en Biomedicina Molecular por el Instituto Politécnico Nacional (IPN).

Químico Biólogo Parasitólogo por la Universidad Autónoma de Guerrero.

Talleres Impartidos: Análisis de DNA: Ciclo Celular. Separación Celular, Detección de Inmunofenotipos, Aplicaciones de Citometría, Curso básico para usuarios de Citometría, Principios básicos de análisis de datos.

Aplicaciones de citometría de flujo implementadas: Detección de Inmunofenotipos, Ciclo celular, Anexina, TUNEL, Aldefluor, Proliferación, Viabilidad por citometría, Análisis de genes reporteros, Separación celular, Estrés oxidativo, Medición de proteínas solubles por arreglos de perlas, como CBA´s o Legendplex.

Artículos

• Jimenez-Ortega RF, Aparicio-Bautista DI, Becerra-Cervera A, Ortega-Melendez AI, Patino N, Rivera-Paredez B, Hidalgo-Bravo A, Velazquez-Cruz R. The Regulatory Role of Long Non-Coding RNAs in the Development and Progression of Osteoporosis. Int J Mol Sci. 2025 Apr 30; 26(9):None.

• Becerra-Cervera A, Jimenez-Ortega RF, Aparicio-Bautista DI, Lopez-Perez TV, Patino N, Castillejos-Lopez M, Hidalgo-Bravo A, Denova-Gutierrez E, Salmeron J, Rivera-Paredez B, Velazquez-Cruz R. Genetic variants in vitamin D metabolism-related genes are associated with vitamin D status and adiposity markers. Nutr Res. 2025 Apr; 136:105-119.

• Jimenez-Ortega RF, Lopez-Perez TV, Becerra-Cervera A, Aparicio-Bautista DI, Patino N, Salas-Martinez G, Salmeron J, Velazquez-Cruz R, Rivera-Paredez B. Impact of the dietary antioxidant index on bone mineral density gain among mexican adults: a prospective study. Arch Osteoporos. 2025 Mar 11; 20(1):38.

• Rivera-Paredez B, Hidalgo-Bravo A, Lopez-Montoya P, Becerra-Cervera A, Patino N, Denova-Gutierrez E, Salmeron J, Velazquez-Cruz R. Skin pigmentation related variants in Mexican population and interaction effects on serum 25(OH)D concentration and vitamin D deficiency. Sci Rep. 2024 Jul 29; 14(1):17378.

• Jimenez-Ortega RF, Ortega-Melendez AI, Patino N, Rivera-Paredez B, Hidalgo-Bravo A, Velazquez-Cruz R. The Involvement of microRNAs in Bone Remodeling Signaling Pathways and Their Role in the Development of Osteoporosis. Biology (Basel). 2024 Jul 7; 13(7):None.

• Rivera-Paredez B, Aparicio-Bautista DI, Argoty-Pantoja AD, Patino N, Flores Morales J, Salmeron J, Leon-Reyes G, Velazquez-Cruz R. Association of MARC1, ADCY5, and BCO1 Variants with the Lipid Profile, Suggests an Additive Effect for Hypertriglyceridemia in Mexican Adult Men. Int J Mol Sci. 2022 Oct 5; 23(19):.

• Romero Y, Balderas-Martinez YI, Vargas-Morales MA, Castillejos-Lopez M, Vazquez-Perez JA, Calyeca J, Torres-Espindola LM, Patino N, Camarena A, Carlos-Reyes A, Flores-Soto E, Leon-Reyes G, Sierra-Vargas MP, Herrera I, Luis-Garcia ER, Ruiz V, Velazquez-Cruz R, Aquino-Galvez A. Effect of Hypoxia in the Transcriptomic Profile of Lung Fibroblasts from Idiopathic Pulmonary Fibrosis. Cells. 2022 OCT; 11(19):None.

• Hidalgo-Bravo A, Rivera-Paredez B, Leon-Reyes G, Patino N, Castillejos-Lopez M, Salmeron J, Velazquez-Cruz R. Unravelling the Contribution of the rs7041 and rs4588 Polymorphisms of the GC Gene and Serum VDBP Levels for Developing Metabolic Syndrome in the Mexican Population. Int J Mol Sci. 2022 Sep 13; 23(18):.

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  Ramirez-Salazar EG, Almeraya EV, Lopez-Perez TV, Jimenez-Salas Z, Patino N, Velazquez-Cruz R. MicroRNA-1270 Inhibits Cell Proliferation, Migration, and Invasion via Targeting IRF8 in Osteoblast-like Cell Lines. Curr Issues Mol Biol. 2022 Mar 1; 44(3):1182-1190.

• Rojas-Ochoa A, Cordova EJ, Carrillo-Garcia A, Lizano M, Pedraza-Chaverri J, Patino N, Cruz-Gregorio A, Osnaya N. The Polyphenols alpha-Mangostin and Nordihydroguaiaretic Acid Induce Oxidative Stress, Cell Cycle Arrest, and Apoptosis in a Cellular Model of Medulloblastoma. Molecules. 2021 Nov 29; 26(23):None.

• Delgadillo-Velazquez JA, Nambo-Venegas R, Patino N, Meraz-Cruz N, Razo-Azamar M, Guevara-Cruz M, Fonseca M, Pale Montero LE, Ibarra-Gonzalez I, Vela-Amieva M, Vadillo-Ortega F, Palacios-Gonzalez B. Metabolic flexibility during normal pregnancy allows appropriate adaptation during gestation independently of BMI. Clin Nutr ESPEN. 2021 Aug; 44:254-262.

• Parra-Torres AY, Enriquez J, Jimenez-Ortega RF, Patino N, Castillejos-Lopez MJ, Torres-Espindola LM, Ramirez-Salazar EG, Velazquez-Cruz R. Expression profiles of the Wnt/beta-catenin signaling-related extracellular antagonists during proliferation and differentiation in human osteoblast-like cells. Exp Ther Med. 2020 Dec; 20(6):254.

• Hidalgo-Bravo A, Hernandez-Medrano C, Sevilla-Montoya R, Rivera-Paredez B, Ramirez-Salazar EG, Flores-Morales J, Patino N, Salmeron J, Valdes-Flores M, Velazquez-Cruz R. Single-nucleotide polymorphism rs10036727 in the SLIT3 gene is associated with osteoporosis at the femoral neck in older Mexican postmenopausal women. Gynecol Endocrinol. 2020 Aug 7; :1-5.

• Ramirez-Salazar EG, Almeraya EV, Lopez-Perez TV, Patino N, Salmeron J, Velazquez-Cruz R. MicroRNA-548-3p overexpression inhibits proliferation, migration, and invasion in osteoblast-like cells by targeting STAT1 and MAFB. J Biochem. 2020 Mar 20; :.

• de Arellano ITR, Lara CS, Espindola LMT, de Jesus Castillejos Lopez M, Prado AJ, Cruz RV, Camacho JLG, Patino N, Bojorquez JDR, Suck MLT. Exposure to biomass smoke, cigarettes, and alcohol modifies the association between tumour necrosis factor (-308G/A, -238G/A) polymorphisms and tuberculosis in Mexican carriers. Arch Med Sci. 2020; 16(3):672-681.

• Hidalgo-Bravo A, Parra-Torres AY, Casas-Avila L, Jimenez-Ortega RF, Ramirez-Salazar EG, Patino N, Rivera-Paredez B, Salmeron J, Valdes-Flores M, Velazquez-Cruz R. Association of RMND1/CCDC170-ESR1 single nucleotide polymorphisms with hip fracture and osteoporosis in postmenopausal women. Climacteric. 2019 Jan 2; 22:1-8.

• Ramirez-Salazar EG, Carrillo-Patino S, Hidalgo-Bravo A, Rivera-Paredez B, Quiterio M, Ramirez-Palacios P, Patino N, Valdes-Flores M, Salmeron J, Velazquez-Cruz R. Serum miRNAs miR-140-3p and miR-23b-3p as potential biomarkers for osteoporosis and osteoporotic fracture in postmenopausal Mexican-Mestizo women. Gene. 2018 Dec 30; 679:19-27.

• Villalobos-Comparan M, Jimenez-Ortega RF, Estrada K, Parra-Torres AY, Gonzalez-Mercado A, Patino N, Castillejos-Lopez M, Quiterio M, Fernandez-Lopez JC, Ibarra B, Romero-Hidalgo S, Salmeron J, Velazquez-Cruz R. A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density. Int J Genomics. 2017; 2017:5831020.