El Dr. Eduardo Martínez Martínez es Investigador en Ciencias Médicas "D" en el Instituto Nacional de Medicina Genómica (INMEGEN) y miembro del Sistema Nacional de Investigadoras e Investigadores (SNII) en el Nivel II. Es egresado de la Licenciatura en Investigación Biomédica Básica y Doctor en Ciencias por la Universidad Nacional Autónoma de México (UNAM), habiendo realizado una estancia posdoctoral en la Escuela de Medicina de la Universidad de Harvard.

Actualmente, dirige el Laboratorio de Comunicación Celular y Vesículas Extracelulares, grupo pionero en México enfocado en el estudio de la biogénesis y caracterización molecular de vesículas extracelulares (VEs). Su trabajo se centra en descifrar los mecanismos de disfunción endolisosomal y mitocondrial asociados a la neurodegeneración, así como en la genómica y la búsqueda de biomarcadores para el diagnóstico temprano y seguimiento de la enfermedad de Parkinson.

Cuenta con más de 40 artículos científicos en revistas internacionales de alto impacto, entre las que destacan el Journal of Extracellular Vesicles, Scientific Reports, Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) y The Journal of Physiology, además de capítulos de libro especializados. Asimismo, mantiene una red de colaboración con Institutos Nacionales de Salud y universidades nacionales e internacionales, combinando la investigación de frontera con la formación de recursos humanos que incluye el mentorazgo de estudiantes de posgrado y posdoctorantes.

Artículos

• Gallegos-Altamirano E, Castillo-Arellano J, Perez Figueroa E, Guevara-Salinas A, Gonzalez-Vilchis E, Morales-Ruiz V, Alvarez-Luquin D, Rodriguez-Violante M, Ichikawa-Escamilla E, Regalado-Mustafa AY, Romero-Rodriguez D, Martinez-Martinez E, Velasco I, Adalid-Peralta L. Pramipexole promotes CD8(+) regulatory T cell-dependent neuroprotection in Parkinson's disease patients. Brain Behav Immun. 2026 Jun 03; 137:106840.

• Alvarez-Luquin DD, Gonzalez-Fernandez RR, Ichikawa-Escamilla E, Torres-Velasco ME, Martinez-Martinez E, Arce-Sillas A, Juarez-Vaquera VH, Miranda-Narvaez CL, Hernandez M, Adalid-Peralta L. Models of neuroprotection in Parkinson's disease: Exploring cellular, molecular, and microenvironmental targets. Exp Neurol. 2026 Apr 11; 402:115764.

• Oropeza Valdez JJ, Elizalde-Diaz JP, Antonio OR, -Hernandez JL, Adalid-Peralta L, Rodriguez-Violante M, Mandal R, Wishart DS, Lopez-Hernandez Y, -Martinez EM. Association of a five-metabolite and early-symptom profile with Parkinson's disease and its clinical progression. Sci Rep. 2026 Jan 21; 16(1):5885.

• Pena-Pena M, Zepeda-Garcia O, Posadas-Sanchez R, Sanchez-Munoz F, Dominguez-Perez M, Martinez-Greene JA, Lopez-Bautista F, Hernandez-Diazcouder A, Jimenez-Ortega RF, Valencia-Cruz AI, Nunez-Salgado A, Mani-Arellano IE, Martinez-Flores K, Villarreal-Molina T, Martinez-Martinez E, Jacobo-Albavera L. A Plasma Extracellular Vesicle-Derived microRNA Signature as a Potential Biomarker for Subclinical Coronary Atherosclerosis. Int J Mol Sci. 2025 Sep 7; 26(17):None.

• Alvarez-Luquin DD, Gonzalez-Fernandez RR, Torres-Velasco ME, Ichikawa-Escamilla E, Arce-Sillas A, Martinez-Martinez E, Miranda-Narvaez CL, Rodriguez-Ramirez JF, Adalid-Peralta L. Neurodegeneration models in Parkinson's disease: cellular and molecular paths to neuron death. Behav Brain Funct. 2025 May 31; 21(1):14.

• Lopez-Cepeda ML, Angarita-Rodriguez A, Rojas-Cruz AF, Perez Mejia J, Khatri R, Brehler M, Martinez-Martinez E, Pinzon A, Aristizabal-Pachon AF, Gonzalez J. Extracellular Competing Endogenous RNA Networks Reveal Key Regulators of Early Amyloid Pathology Propagation in Alzheimer's Disease. Int J Mol Sci. 2025 Apr 9; 26(8):None.

• Carvajal-Oliveros A, Roman-Martinez C, Reynaud E, Martinez-Martinez E. The BE (2)-M17 neuroblastoma cell line: revealing its potential as a cellular model for Parkinson's disease. Front Cell Neurosci. 2024 Dec 11; 18:1485414.

• Itzel CG, Eduardo MM, Velia RA, Mireya CV, Alfredo HM, Pilar RMD, Gabriela AS. Salivary Extracellular Vesicles Separation: Analysis of Ultracentrifugation-Based Protocols. Oral Dis. 2024 Oct 27; 31(3):879-889.

• Cruz-Burgos M, Cortes-Ramirez SA, Losada-Garcia A, Morales-Pacheco M, Martinez-Martinez E, Morales-Montor JG, Servin-Haddad A, Izquierdo-Luna JS, Rodriguez-Martinez G, Ramos-Godinez MDP, Gonzalez-Covarrubias V, Canavera-Constantino A, Gonzalez-Ramirez I, Su B, Leong HS, Rodriguez-Dorantes M. Unraveling the Role of EV-Derived miR-150-5p in Prostate Cancer Metastasis and Its Association with High-Grade Gleason Scores: Implications for Diagnosis. Cancers (Basel). 2023 Aug 17; 15(16):None.

• Martinez-Greene JA, Gomez-Chavarin M, Ramos-Godinez MDP, Martinez-Martinez E. Isolation of Hepatic and Adipose-Tissue-Derived Extracellular Vesicles Using Density Gradient Separation and Size Exclusion Chromatography. Int J Mol Sci. 2023 Aug 11; 24(16):None.

• Lopez-Hernandez Y, Monarrez-Espino J, Lopez DAG, Zheng J, Borrego JC, Torres-Calzada C, Elizalde-Diaz JP, Mandal R, Berjanskii M, Martinez-Martinez E, Lopez JA, Wishart DS. The plasma metabolome of long COVID patients two years after infection. Sci Rep. 2023 Aug 1; 13(1):12420.

• Garcia-Hernandez LA, Martinez-Martinez E, Pazos-Solis D, Aguado-Preciado J, Dutt A, Chavez-Ramirez AU, Korgel B, Sharma A, Oza G. Optical Detection of Cancer Cells Using Lab-on-a-Chip. Biosensors (Basel). 2023 Mar 30; 13(4):None.

• Gonzalez-Pedroza MG, Benitez ART, Navarro-Marchal SA, Martinez-Martinez E, Marchal JA, Boulaiz H, Morales-Luckie RA. Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications. Sci Rep. 2023 Jan 16; 13(1):790.

• Carapia AK, Martinez-Colin EJ, Segura-Villalobos D, Victoria-Chavez RY, Lezama I, Martinez-Martinez E, Lamas M. Muller Glia to Muller Glia Extracellular Vesicle-Dependent Signaling Induces Multipotency Genes Nestin and lin28 Expression in Response to N-methyl-D-aspartate (NMDA) Exposure. ASN Neuro. 2023 Jan-Dec; 15:17590914231183272.

• Elizalde-Diaz JP, Miranda-Narvaez CL, Martinez-Lazcano JC, Martinez-Martinez E. The relationship between chronic immune response and neurodegenerative damage in long COVID-19. Front Immunol. 2022 DEC 16; 13:None.

• Perez-Macedonio CP, Flores-Alfaro E, Alarcon-Romero LD, Vences-Velazquez A, Castro-Alarcon N, Martinez-Martinez E, Ramirez M. CD 14 and CD26 from serum exosomes are associated with type 2 diabetes, exosomal Cystatin C and CD14 are associated with metabolic syndrome and atherogenic index of plasma. PeerJ. 2022 JUL 12; 10:None.

• Gonzalez-Covarrubias V, Martinez-Martinez E, Del Bosque-Plata L. The Potential of Metabolomics in Biomedical Applications. Metabolites. 2022 Feb 19; 12(2):None.

• Ballinas-Verdugo MA, Jimenez-Ortega RF, Martinez-Martinez E, Rivas N, Contreras-Lopez EA, Carbo R, Sanchez F, Bojalil R, Marquez-Velasco R, Sanchez-Munoz F, Alejandre-Aguilar R. Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease. Biol Res. 2021 Jul 21; 54(1):21.

• Del Bosque-Plata L, Martinez-Martinez E, Espinoza-Camacho MA, Gragnoli C. The Role of TCF7L2 in Type 2 Diabetes. Diabetes. 2021 Jun; 70(6):1220-1228.

• Hernandez-Diazcouder A, Gonzalez-Ramirez J, Giacoman-Martinez A, Cardoso-Saldana G, Martinez-Martinez E, Osorio-Alonso H, Marquez-Velasco R, Sanchez-Gloria JL, Juarez-Vicuna Y, Gonzaga G, Sanchez-Lozada LG, Almanza-Perez JC, Sanchez-Munoz F. High fructose exposure modifies the amount of adipocyte-secreted microRNAs into extracellular vesicles in supernatants and plasma. PeerJ. 2021; 9:e11305.

• Gonzalez-Pedroza MG, Argueta-Figueroa L, Garcia-Contreras R, Jimenez-Martinez Y, Martinez-Martinez E, Navarro-Marchal SA, Marchal JA, Morales-Luckie RA, Boulaiz H. Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool. Nanomaterials (Basel). 2021 May 12; 11(5):.

• Velazquez-Vazquez DE, Del Moral-Morales A, Cruz-Burgos JM, Martinez-Martinez E, Rodriguez-Dorantes M, Camacho-Alpharroyo I. Expression analysis of progesteroneregulated miRNAs in cells derived from human glioblastoma. Mol Med Rep. 2021 Jun; 23(6):.

• Martinez-Greene JA, Hernandez-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godinez MDP, Martinez-Martinez E. Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. J Extracell Vesicles. 2021 Apr; 10(6):e12087.

• Quiroz-Baez R, Hernandez-Ortega K, Martinez-Martinez E. Insights Into the Proteomic Profiling of Extracellular Vesicles for the Identification of Early Biomarkers of Neurodegeneration. Front Neurol. 2020; 11:580030.

• Herrera-Van Oostdam AS, Toro-Ortiz JC, Lopez JA, Noyola DE, Garcia-Lopez DA, Duran-Figueroa NV, Martinez-Martinez E, Portales-Perez DP, Salgado-Bustamante M, Lopez-Hernandez Y. Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation. Int J Mol Med. 2020 Aug; 46(2):546-560.

• Castillo X, Castro-Obregon S, Gutierrez-Becker B, Gutierrez-Ospina G, Karalis N, Khalil AA, Lopez-Noguerola JS, Rodriguez LL, Martinez-Martinez E, Perez-Cruz C, Perez-Velazquez J, Pina AL, Rubio K, Garcia HPS, Syeda T, Vanoye-Carlo A, Villringer A, Winek K, Zille M. Re-thinking the Etiological Framework of Neurodegeneration. Front Neurosci. 2019; 13:728.

• Nagy E, Lei Y, Martinez-Martinez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E. Interferon-gamma Released by Activated CD8(+) T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves. Am J Pathol. 2017 Jun; 187(6):1413-1425.

• Brianza-Padilla M, Carbo R, Arana JC, Vazquez-Palacios G, Ballinas-Verdugo MA, Cardoso-Saldana GC, Palacio AG, Juarez-Vicuna Y, Sanchez F, Martinez-Martinez E, Huang F, Sanchez-Munoz F, Bojalil R. Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. Biomed Res Int. 2016; 2016:2489479.

• Krohn JB, Hutcheson JD, Martinez-Martinez E, Aikawa E. Extracellular vesicles in cardiovascular calcification: expanding current paradigms. J Physiol. 2016 Jun 1; 594(11):2895-903.

• Krohn JB, Hutcheson JD, Martinez-Martinez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E. Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-beta Signaling. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):525-33.

• Martinez-Martinez E, Uribe-Querol E, Galvan-Hernandez CI, Gutierrez-Ospina G. Stereological Quantification of Cell-Cycle Kinetics and Mobilization of Epithelial Stem Cells during Wound Healing. Methods Mol Biol. 2016; 1453:93-107.

• Martinez-Martinez E, Zaragoza ML, Solano E, Figueroa B, Zuniga P, Laclette JP. Health research funding in Mexico: the need for a long-term agenda. PLoS One. 2012; 7(12):e51195.

• Martinez-Martinez E, Galvan-Hernandez CI, Toscano-Marquez B, Gutierrez-Ospina G. Modulatory role of sensory innervation on hair follicle stem cell progeny during wound healing of the rat skin. PLoS One. 2012; 7(5):e36421.

• Martinez-Martinez E, Toscano-Marquez B, Gutierrez-Ospina G. Long-term effects of neonatal capsaicin treatment on intraepidermal nerve fibers and keratinocyte proliferation in rat glabrous skin. Anat Rec (Hoboken). 2011 Jan; 294(1):173-84.

• Toscano-Marquez B, Martinez-Martinez E, Manjarrez E, Martinez L, Mendoza-Torreblanca J, Gutierrez-Ospina G. Late onset muscle plasticity in the whisker pad of enucleated rats. Proc Natl Acad Sci USA. 2008 Oct 14; 105(41):15973-8.

• Mendoza-Torreblanca JG, Martinez-Martinez E, Tapia-Rodriguez M, Ramirez-Hernandez R, Gutierrez-Ospina G. The rostral migratory stream is a neurogenic niche that predominantly engenders periglomerular cells: in vivo evidence in the adult rat brain. Neurosci Res. 2008 Mar; 60(3):289-99.

• Uribe-Querol E, Martinez-Martinez E, Tapia-Rodriguez M, Hernandez LR, Toscano-Marquez B, Padilla P, Gutierrez-Ospina G. Metabolic indices shift in the hypothalamic-neurohypophysial system during lactation: implications for interpreting their relationship with neuronal activity. Neuroscience. 2005; 134(4):1217-22.

• Zomosa-Signoret V, Hernandez-Alcantara G, Reyes-Vivas H, Martinez-Martinez E, Garza-Ramos G, Perez-Montfort R, Tuena De Gomez-Puyou M, Gomez-Puyou A. Control of the reactivation kinetics of homodimeric triosephosphate isomerase from unfolded monomers. Biochemistry. 2003 Mar 25; 42(11):3311-8.

• Reyes-Vivas H, Martinez-Martinez E, Mendoza-Hernandez G, Lopez-Velazquez G, Perez-Montfort R, Tuena de Gomez-Puyou M, Gomez-Puyou A. Susceptibility to proteolysis of triosephosphate isomerase from two pathogenic parasites: characterization of an enzyme with an intact and a nicked monomer. Proteins. 2002 Aug 15; 48(3):580-90.

Tesista de Maestría

• Camila Montserrat Román Martínez

En curso

• Bases genéticas de la enfermedad de Parkinson en la población mexicana: hacia un enfoque proteogenómico para la búsqueda de biomarcadores
• Estudio del perfil de expresión de miRNAs de vesículas extracelulares y mecanismos moleculares involucrados en el desarrollo de la aterosclerosis

Terminados

• Análisis de vesículas extracelulares con perspectiva de uso en diagnóstico y terapia molecular
• Análisis proteómico y funcional de vesículas extracelulares: implicaciones fisiológicas de la comunicación intercelular en la diabetes.
• Análisis sistemático de vesículas extracelulares con perspectiva de uso en la terapia molecular basada en RNA para el tratamiento de la enfermedad de Parkinson y Diabetes Tipo 2.
• Desarrollo de tecnologías para el cargado de complejos ribonucleoproteínicos en vesículas extracelulares para su uso como vehículos de entrega a células en cultivo.
• Identificación de biomarcadores presentes en exosomas en familias con historial de diabetes y enfermedad de Parkinson