El Dr. Eduardo Martínez es egresado de la licenciatura en Investigación Biomédica Básica y del doctorado en Ciencias Biomédicas de la UNAM. Realizó una estancia posdoctoral en la Universidad de Harvard. Actualmente es Investigador en Ciencias Médicas “D” y miembro del Sistema Nacional de Investigadores Nivel I. El Dr. Martínez forma parte del Instituto Nacional de Medicina Genómica y es titular del laboratorio de Comunicación Celular y Vesículas Extracelulares. Sus líneas de investigación están enfocadas a entender el papel de las vesículas extracelulares en la comunicación celular, a investigar los mecanismos celulares relacionados con el desarrollo de enfermedades neurodegenerativas y a estudiar la genómica de la enfermedad de Parkinson.

Ha publicado 39 artículos de investigación en revistas internacionales y 8 capítulos de libro. Estos resultados han sido publicados en revistas de alto impacto como Journal of Extracellular Vesicles, Journal of Phisiology, ATVB, Plos One y PNAS.

Artículos

• Pena-Pena M, Zepeda-Garcia O, Posadas-Sanchez R, Sanchez-Munoz F, Dominguez-Perez M, Martinez-Greene JA, Lopez-Bautista F, Hernandez-Diazcouder A, Jimenez-Ortega RF, Valencia-Cruz AI, Nunez-Salgado A, Mani-Arellano IE, Martinez-Flores K, Villarreal-Molina T, Martinez-Martinez E, Jacobo-Albavera L. A Plasma Extracellular Vesicle-Derived microRNA Signature as a Potential Biomarker for Subclinical Coronary Atherosclerosis. Int J Mol Sci. 2025 Sep 7; 26(17):None.

• Alvarez-Luquin DD, Gonzalez-Fernandez RR, Torres-Velasco ME, Ichikawa-Escamilla E, Arce-Sillas A, Martinez-Martinez E, Miranda-Narvaez CL, Rodriguez-Ramirez JF, Adalid-Peralta L. Neurodegeneration models in Parkinson's disease: cellular and molecular paths to neuron death. Behav Brain Funct. 2025 May 31; 21(1):14.

• Lopez-Cepeda ML, Angarita-Rodriguez A, Rojas-Cruz AF, Perez Mejia J, Khatri R, Brehler M, Martinez-Martinez E, Pinzon A, Aristizabal-Pachon AF, Gonzalez J. Extracellular Competing Endogenous RNA Networks Reveal Key Regulators of Early Amyloid Pathology Propagation in Alzheimer's Disease. Int J Mol Sci. 2025 Apr 9; 26(8):None.

• Carvajal-Oliveros A, Roman-Martinez C, Reynaud E, Martinez-Martinez E. The BE (2)-M17 neuroblastoma cell line: revealing its potential as a cellular model for Parkinson's disease. Front Cell Neurosci. 2024 Dec 11; 18:1485414.

• Itzel CG, Eduardo MM, Velia RA, Mireya CV, Alfredo HM, Pilar RMD, Gabriela AS. Salivary Extracellular Vesicles Separation: Analysis of Ultracentrifugation-Based Protocols. Oral Dis. 2024 Oct 27; 31(3):879-889.

• Cruz-Burgos M, Cortes-Ramirez SA, Losada-Garcia A, Morales-Pacheco M, Martinez-Martinez E, Morales-Montor JG, Servin-Haddad A, Izquierdo-Luna JS, Rodriguez-Martinez G, Ramos-Godinez MDP, Gonzalez-Covarrubias V, Canavera-Constantino A, Gonzalez-Ramirez I, Su B, Leong HS, Rodriguez-Dorantes M. Unraveling the Role of EV-Derived miR-150-5p in Prostate Cancer Metastasis and Its Association with High-Grade Gleason Scores: Implications for Diagnosis. Cancers (Basel). 2023 Aug 17; 15(16):None.

• Martinez-Greene JA, Gomez-Chavarin M, Ramos-Godinez MDP, Martinez-Martinez E. Isolation of Hepatic and Adipose-Tissue-Derived Extracellular Vesicles Using Density Gradient Separation and Size Exclusion Chromatography. Int J Mol Sci. 2023 Aug 11; 24(16):None.

• Lopez-Hernandez Y, Monarrez-Espino J, Lopez DAG, Zheng J, Borrego JC, Torres-Calzada C, Elizalde-Diaz JP, Mandal R, Berjanskii M, Martinez-Martinez E, Lopez JA, Wishart DS. The plasma metabolome of long COVID patients two years after infection. Sci Rep. 2023 Aug 1; 13(1):12420.

• Garcia-Hernandez LA, Martinez-Martinez E, Pazos-Solis D, Aguado-Preciado J, Dutt A, Chavez-Ramirez AU, Korgel B, Sharma A, Oza G. Optical Detection of Cancer Cells Using Lab-on-a-Chip. Biosensors (Basel). 2023 Mar 30; 13(4):None.

• Gonzalez-Pedroza MG, Benitez ART, Navarro-Marchal SA, Martinez-Martinez E, Marchal JA, Boulaiz H, Morales-Luckie RA. Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications. Sci Rep. 2023 Jan 16; 13(1):790.

• Carapia AK, Martinez-Colin EJ, Segura-Villalobos D, Victoria-Chavez RY, Lezama I, Martinez-Martinez E, Lamas M. Muller Glia to Muller Glia Extracellular Vesicle-Dependent Signaling Induces Multipotency Genes Nestin and lin28 Expression in Response to N-methyl-D-aspartate (NMDA) Exposure. ASN Neuro. 2023 Jan-Dec; 15:17590914231183272.

• Elizalde-Diaz JP, Miranda-Narvaez CL, Martinez-Lazcano JC, Martinez-Martinez E. The relationship between chronic immune response and neurodegenerative damage in long COVID-19. Front Immunol. 2022 DEC 16; 13:None.

• Perez-Macedonio CP, Flores-Alfaro E, Alarcon-Romero LD, Vences-Velazquez A, Castro-Alarcon N, Martinez-Martinez E, Ramirez M. CD 14 and CD26 from serum exosomes are associated with type 2 diabetes, exosomal Cystatin C and CD14 are associated with metabolic syndrome and atherogenic index of plasma. PeerJ. 2022 JUL 12; 10:None.

• Gonzalez-Covarrubias V, Martinez-Martinez E, Del Bosque-Plata L. The Potential of Metabolomics in Biomedical Applications. Metabolites. 2022 Feb 19; 12(2):None.

• Ballinas-Verdugo MA, Jimenez-Ortega RF, Martinez-Martinez E, Rivas N, Contreras-Lopez EA, Carbo R, Sanchez F, Bojalil R, Marquez-Velasco R, Sanchez-Munoz F, Alejandre-Aguilar R. Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease. Biol Res. 2021 Jul 21; 54(1):21.

• Del Bosque-Plata L, Martinez-Martinez E, Espinoza-Camacho MA, Gragnoli C. The Role of TCF7L2 in Type 2 Diabetes. Diabetes. 2021 Jun; 70(6):1220-1228.

• Hernandez-Diazcouder A, Gonzalez-Ramirez J, Giacoman-Martinez A, Cardoso-Saldana G, Martinez-Martinez E, Osorio-Alonso H, Marquez-Velasco R, Sanchez-Gloria JL, Juarez-Vicuna Y, Gonzaga G, Sanchez-Lozada LG, Almanza-Perez JC, Sanchez-Munoz F. High fructose exposure modifies the amount of adipocyte-secreted microRNAs into extracellular vesicles in supernatants and plasma. PeerJ. 2021; 9:e11305.

• Gonzalez-Pedroza MG, Argueta-Figueroa L, Garcia-Contreras R, Jimenez-Martinez Y, Martinez-Martinez E, Navarro-Marchal SA, Marchal JA, Morales-Luckie RA, Boulaiz H. Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool. Nanomaterials (Basel). 2021 May 12; 11(5):.

• Velazquez-Vazquez DE, Del Moral-Morales A, Cruz-Burgos JM, Martinez-Martinez E, Rodriguez-Dorantes M, Camacho-Alpharroyo I. Expression analysis of progesteroneregulated miRNAs in cells derived from human glioblastoma. Mol Med Rep. 2021 Jun; 23(6):.

• Martinez-Greene JA, Hernandez-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godinez MDP, Martinez-Martinez E. Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. J Extracell Vesicles. 2021 Apr; 10(6):e12087.

• Quiroz-Baez R, Hernandez-Ortega K, Martinez-Martinez E. Insights Into the Proteomic Profiling of Extracellular Vesicles for the Identification of Early Biomarkers of Neurodegeneration. Front Neurol. 2020; 11:580030.

• Herrera-Van Oostdam AS, Toro-Ortiz JC, Lopez JA, Noyola DE, Garcia-Lopez DA, Duran-Figueroa NV, Martinez-Martinez E, Portales-Perez DP, Salgado-Bustamante M, Lopez-Hernandez Y. Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation. Int J Mol Med. 2020 Aug; 46(2):546-560.

• Castillo X, Castro-Obregon S, Gutierrez-Becker B, Gutierrez-Ospina G, Karalis N, Khalil AA, Lopez-Noguerola JS, Rodriguez LL, Martinez-Martinez E, Perez-Cruz C, Perez-Velazquez J, Pina AL, Rubio K, Garcia HPS, Syeda T, Vanoye-Carlo A, Villringer A, Winek K, Zille M. Re-thinking the Etiological Framework of Neurodegeneration. Front Neurosci. 2019; 13:728.

• Nagy E, Lei Y, Martinez-Martinez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E. Interferon-gamma Released by Activated CD8(+) T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves. Am J Pathol. 2017 Jun; 187(6):1413-1425.

• Brianza-Padilla M, Carbo R, Arana JC, Vazquez-Palacios G, Ballinas-Verdugo MA, Cardoso-Saldana GC, Palacio AG, Juarez-Vicuna Y, Sanchez F, Martinez-Martinez E, Huang F, Sanchez-Munoz F, Bojalil R. Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. Biomed Res Int. 2016; 2016:2489479.

• Krohn JB, Hutcheson JD, Martinez-Martinez E, Aikawa E. Extracellular vesicles in cardiovascular calcification: expanding current paradigms. J Physiol. 2016 Jun 1; 594(11):2895-903.

• Krohn JB, Hutcheson JD, Martinez-Martinez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E. Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-beta Signaling. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):525-33.

• Martinez-Martinez E, Uribe-Querol E, Galvan-Hernandez CI, Gutierrez-Ospina G. Stereological Quantification of Cell-Cycle Kinetics and Mobilization of Epithelial Stem Cells during Wound Healing. Methods Mol Biol. 2016; 1453:93-107.

• Martinez-Martinez E, Zaragoza ML, Solano E, Figueroa B, Zuniga P, Laclette JP. Health research funding in Mexico: the need for a long-term agenda. PLoS One. 2012; 7(12):e51195.

• Martinez-Martinez E, Galvan-Hernandez CI, Toscano-Marquez B, Gutierrez-Ospina G. Modulatory role of sensory innervation on hair follicle stem cell progeny during wound healing of the rat skin. PLoS One. 2012; 7(5):e36421.

• Martinez-Martinez E, Toscano-Marquez B, Gutierrez-Ospina G. Long-term effects of neonatal capsaicin treatment on intraepidermal nerve fibers and keratinocyte proliferation in rat glabrous skin. Anat Rec (Hoboken). 2011 Jan; 294(1):173-84.

• Toscano-Marquez B, Martinez-Martinez E, Manjarrez E, Martinez L, Mendoza-Torreblanca J, Gutierrez-Ospina G. Late onset muscle plasticity in the whisker pad of enucleated rats. Proc Natl Acad Sci USA. 2008 Oct 14; 105(41):15973-8.

• Mendoza-Torreblanca JG, Martinez-Martinez E, Tapia-Rodriguez M, Ramirez-Hernandez R, Gutierrez-Ospina G. The rostral migratory stream is a neurogenic niche that predominantly engenders periglomerular cells: in vivo evidence in the adult rat brain. Neurosci Res. 2008 Mar; 60(3):289-99.

• Uribe-Querol E, Martinez-Martinez E, Tapia-Rodriguez M, Hernandez LR, Toscano-Marquez B, Padilla P, Gutierrez-Ospina G. Metabolic indices shift in the hypothalamic-neurohypophysial system during lactation: implications for interpreting their relationship with neuronal activity. Neuroscience. 2005; 134(4):1217-22.

• Zomosa-Signoret V, Hernandez-Alcantara G, Reyes-Vivas H, Martinez-Martinez E, Garza-Ramos G, Perez-Montfort R, Tuena De Gomez-Puyou M, Gomez-Puyou A. Control of the reactivation kinetics of homodimeric triosephosphate isomerase from unfolded monomers. Biochemistry. 2003 Mar 25; 42(11):3311-8.

• Reyes-Vivas H, Martinez-Martinez E, Mendoza-Hernandez G, Lopez-Velazquez G, Perez-Montfort R, Tuena de Gomez-Puyou M, Gomez-Puyou A. Susceptibility to proteolysis of triosephosphate isomerase from two pathogenic parasites: characterization of an enzyme with an intact and a nicked monomer. Proteins. 2002 Aug 15; 48(3):580-90.

Servicio Social

• Elizabeth Rueda Toscano

Tesista de Maestría

• Camila Montserrat Román Martínez

En curso

• Bases genéticas de la enfermedad de Parkinson en la población mexicana: hacia un enfoque proteogenómico para la búsqueda de biomarcadores
• Estudio del perfil de expresión de miRNAs de vesículas extracelulares y mecanismos moleculares involucrados en el desarrollo de la aterosclerosis

Terminados

• Análisis de vesículas extracelulares con perspectiva de uso en diagnóstico y terapia molecular
• Análisis proteómico y funcional de vesículas extracelulares: implicaciones fisiológicas de la comunicación intercelular en la diabetes.
• Análisis sistemático de vesículas extracelulares con perspectiva de uso en la terapia molecular basada en RNA para el tratamiento de la enfermedad de Parkinson y Diabetes Tipo 2.
• Desarrollo de tecnologías para el cargado de complejos ribonucleoproteínicos en vesículas extracelulares para su uso como vehículos de entrega a células en cultivo.
• Identificación de biomarcadores presentes en exosomas en familias con historial de diabetes y enfermedad de Parkinson